Syphilis is a chronic and classic sexually transmitted disease caused by the pale spirochete, which invades almost all organs of the body and produces a variety of signs and symptoms, especially in the late stages of syphilis, which is more dangerous. Syphilis may also be asymptomatic for many years and be latent, which is known as latent syphilis. The main way of transmission of syphilis is through sexual intercourse, but it can also be transmitted to the next generation through the placenta. 1, sexual contact This is the main way of transmission. Untreated patients are the most infectious within 1 year after infection, with the lengthening of the disease, the infectiousness is becoming less and less, to 2 years after infection, through sexual contact is generally not infectious. 2, fetal transmission Pregnant women with syphilis can be infected through the placenta is the fetus. Studies have shown that at 7 weeks of gestation, syphilis spirochetes can pass through the placenta, but before 5 months, the fetus may not be infected, probably because the fetus is not yet able to inflammatory response. 3, other than a few can be transmitted through sexual contact, direct contact: such as kissing, breastfeeding, etc.; indirect contact warts infectious damage to the patient’s daily necessities, such as clothes, towels, razors, cutlery and cigarettes, etc. The patient was seen in the urology department of another hospital and was admitted to the hospital for surgical treatment of “perianal verrucae”. The first choice of treatment: benzathine penicillin 2.4 million U injected intramuscularly on both sides of the buttocks once a week for 3 times.