Depressive episodes can cause a lot of pain to the patient, including the adverse effects on the family to varying degrees, therefore, after the patient visits the doctor, they hope that the doctor can “cure the disease”, and can not wait to restore health. This is a common feeling, which is understandable and should be respected. But unfortunately, the development of objective things have their own laws, and often do not always meet the good wishes of people. Antidepressant treatment has its own basic rules. Generally speaking, antidepressants take effect gradually after 1-2 weeks, and in the case of a smooth transition, the condition will improve significantly or return to the normal state after 6-8 weeks. Understanding this relatively slow onset of antidepressants is important for patients to be able to adhere to the medication. The first 1 week of antidepressant medication, generally will not appear very obvious efficacy, but adverse reactions may appear after taking once, such as dizziness, dizziness or even headache, nausea and stomach distension and other gastrointestinal symptoms are more common reactions, at this time, some patients may experience, antidepressants do not eat okay, but eat the disease but more serious, it is easy to stop the medication, so that the follow-up treatment is difficult to carry out. What to do? First of all, it should be noted that most of the patients’ reactions are not heavy, and most of them are within the range of “tolerable” persistence, so they should insist on taking the medication or reduce the original starting dose by half, and after 2-4 days, these reactions will generally be reduced, and then increase the dose to the original dose. Of course, if new adverse reactions appear after taking the drug, that is, symptoms that were not present before taking the drug, are more serious, so that you can hardly tolerate them, or, after insisting on taking the drug for about 1 week, the adverse reactions gradually worsen, then it suggests that the drug may not be suitable for this patient, you can temporarily stop using it and go to the hospital as soon as possible to follow up, and ask the doctor to further evaluate its applicability to decide whether to change the drug. In the case that the drug is suitable for the patient, the condition will improve after 1-2 weeks of taking it, and the manifestation of some symptoms will start to reduce. Finally, it is emphasized that no single antidepressant can be suitable for all depressed patients, and different patients may have very different reactions to the same medication. Therefore, prescription medication such as antidepressants should be observed and guided by the doctor, and the doctor will advise when it can be discontinued or needs to be changed to other medications in due course according to the situation at the follow-up visit. Therefore, it is important to have regular follow-ups. If it is the first time you take the medication, it is recommended to follow up after 2 weeks of taking the medication, and thereafter, you can follow up every 2-6 weeks depending on the response to the medication and changes in your condition. After the disease has stabilized, that is, the symptoms have basically disappeared and the ability to live and work has basically returned to normal, you should also insist on regular follow-ups and should not decide to stop taking the medication on your own. Especially for patients who have experienced fluctuations or even relapse soon after stopping the medication, it is necessary to insist on regular follow-ups and, if necessary, to participate in rehabilitation treatment, or to combine systematic psychotherapy.