The liver is the largest detoxification organ in the body, and most drugs are broken down and metabolized in the liver. Anti-tuberculosis drugs are mainly metabolized in the body by the liver and excreted by the kidneys. Therefore, they have effects on both organs. Commonly used anti-tuberculosis drugs include isoniazid, rifampin, streptomycin, pyrazinamide, ethambutol, sodium para-aminosalicylate, prothiouracil, aminothiourea, kanamycin, capreomycin, etc. Except for streptomycin, kanamycin and capreomycin, which are mainly for hearing damage and kidney damage, all other drugs have liver function damage and gastrointestinal symptoms as the main side effects. In addition, regular anti-tuberculosis treatment is composed of 2-4 drugs, many of which have liver damage, and the side effects increase when added to each other. Fatal acute and subacute hepatic necrosis can occur after a few doses of rifampin in a few patients, especially those with abnormal liver function. Therefore, liver function must be tested before taking rifampicin. During the initial period of anti-tuberculosis drug application (usually within a few weeks), some patients may develop elevated glutathione transaminase (GPT), hepatomegaly and jaundice. This drug-induced elevation of transaminases, hepatomegaly, and jaundice is called drug-induced hepatitis or toxic hepatitis. Most of these patients have asymptomatic transient elevations of transaminases, which can recover on their own. Therefore, if transaminases are mildly elevated during treatment, in addition to the application of liver-protective drugs, liver function should be reviewed regularly to observe the trend of transaminase changes, and there is no need to hastily stop or reduce the dosage. If the transaminases increase progressively, or if jaundice and obvious hepatitis appear, please reduce the dosage, change the medication or stop the medication under the guidance of the doctor. Both outpatients and inpatients should have their liver function checked once a month while taking anti-tuberculosis drugs, as well as taking liver-protective drugs and vitamins.