Liver cancer is insidious and very dangerous, and is known as an invisible killer. Early stage liver cancer usually does not produce any disease, so it is also called disease-free period, which may vary from a few months to a few years, depending on the patient. It is common for patients with liver cancer to visit the doctor with extrahepatic symptoms, and the lump in the liver area has increased to several centimeters or even ten centimeters, which makes the doctor sigh with regret that the patient has missed the best time for treatment. Pain in the liver, loss of appetite, abdominal distention, indigestion, nausea, vomiting, weakness and emaciation mostly appear in the middle and late stages of the disease. Jaundice, ascites, itchy skin, bleeding phenomenon, hepatomegaly, fever, and systemic failure, severe weakness, emaciation, progressive anemia and edema appear more in the terminal stage, which is a great dilemma for patients, families and clinicians. So, are there any clues for early stage liver cancer? The answer is yes. As long as one has enough knowledge and vigilance about liver cancer, some clues can still be found. The following is an introduction of atypical symptoms related to liver cancer that may be encountered in clinical practice. 1. Fatigue. Fatigue is the most common symptom of liver cancer, and also the most easily ignored symptom by most people. According to a relatively professional symptom group analysis, fatigue tops the list of symptoms of liver cancer patients, with an incidence rate of 74.9%, and tops the severity rating and distress degree of patients. Therefore, one should be highly alert to unexplained fatigue and have timely examination. 2, nausea and bloating abdominal pain is not always the problem of the “stomach”. Stomach pain epigastric pain is a symptom that many people suffer from, but do not look deeper and do not take seriously. Some of them have mild indigestion and other symptoms, such as epigastric discomfort, mild fullness, pain, nausea, belching, etc. These symptoms are not unique to liver cancer, but can be seen in chronic inflammation, ulcer disease, functional indigestion, and even normal people occasionally. According to incomplete statistics, about 37% of liver disease patients mistook “stomach disease” for “stomach disease” at the early stage of the disease and missed the treatment. Liver disease can be easily confused with stomach disease because of the atypical symptoms at the beginning of the disease, such as loss of appetite, nausea, abdominal distension, and upper abdominal discomfort. If you have symptoms of suspected gastrointestinal disease, you should not take medication on your own, but go to the hospital for a clear diagnosis, especially if you are a frequent drinker, carry the hepatitis B virus or have a history of biliary tract disease. If patients treat liver disease as stomach disease for a long time and take medication without permission, the result is likely to make hepatitis develop into advanced cirrhosis or liver cancer, missing the best time for treatment. 3. Feverish sweating. Frequent excessive sweating and false sweating rank 6th in the statistical symptoms. It may be accompanied by low fever. Giant hepatocellular carcinoma may have hyperthermia because of central ischemic necrosis of the carcinoma, and ineffective treatment with antibiotics is its characteristic. Any persistent hypothermia with excessive sweating or hyperthermia and ineffective antibiotic treatment should be considered as a possibility of hepatocellular carcinoma. 4. Chest pain and cough may also be related to liver cancer. Liver is adjacent to diaphragm and pleura, and liver cancer immediately adjacent to diaphragm may invade pleura at an early stage, resulting in recurrent and incurable cough or chest pain, which should not be ignored. Because they are also the most common early symptoms of hepatocellular carcinoma, however, most of the patients with hepatocellular carcinoma mainly show boring pain, as well as there is also hidden pain, the location is not certain, so that the relationship between this and breathing is also uncertain. If the pain is persistent, it means that the cancer of liver cancer may involve the pleura in many cases. 5. Hypoglycemia. The liver itself has strong compensatory ability, and only when the area of liver damage exceeds 70% to 80%, there will be obvious hypoglycemia, which is manifested as dizziness, weakness, sweating and other symptoms. 6. Erythrocytosis. Patients with long-term cirrhosis or chronic liver disease with no other reason for erythrocytosis may be an early sign of liver cancer and should be paid great attention. Because, when cancer cells of liver divide, they produce a lot of erythropoietin, resulting in excessive erythropoiesis. However, the increase in red blood cells in liver cancer patients is not accompanied by an increase in white blood cells, platelets and lymphocytes. Therefore, a higher erythrocyte count indicates a more vigorous cell division in hepatocellular carcinoma. The clinical manifestations are red face, polycythemia physical appearance, etc. 7. Hyperlipidemia. In patients with cirrhosis and chronic hepatitis, if hyperlipidemia is still present despite the exclusion of high-fat diet, heavy alcohol consumption, lack of exercise and certain endocrine diseases, it is also regarded as a sign of liver cancer. Clinically, the symptoms and signs of hyperlipidemia, such as obesity and atherosclerosis, are manifested. 8. Symptoms of paraneoplastic syndrome. Such symptoms, related to the secretion of hormones by tumor cells, have various manifestations. 9.Change in eating taste. Change in eating taste, the 12th most frequent, is seen in slightly more than 1/3 of patients. Most of them have symptoms such as bitter mouth and aversion to greasy food because of abnormal bile metabolism. The above symptoms, if not carefully analyzed, can easily lead the diagnosis and treatment astray. Therefore, both patients and clinicians should carefully trace the root cause of the above symptoms. As a reminder, the initial symptoms of liver disease are often atypical, so patients often delay treatment. Physical examination is an effective means of detecting liver disease in a timely manner, and the general public should have an annual liver examination. Hepatitis B virus carriers, cirrhotic patients, long-term alcoholics, and people with mildly elevated alpha-fetoprotein are among the high-risk groups for liver cancer and should be examined every three months even if they have no uncomfortable symptoms.