Where syphilis grows varies greatly depending on the stage of syphilis. Stage I syphilis is characterized by hard chancre, which can occur on the penis, glans, coronal sulcus, foreskin and urethra in men; in women, it can occur on the labia, clitoris and cervix; and in some patients, it can occur on the anus, anal canal, lips, tongue and breasts. Stage II syphilis is mainly characterized by syphilis rash, which can occur in the skin and mucous membrane, and even in the bones and joints and nerves. In stage III syphilis, the nodular syphilis rash occurs on the scalp, scapula and extremities, mainly on the extensor side. Dendritic swellings may occur on the lower legs, as well as nodules near the joints, and some patients may develop cardiovascular and neurological syphilis in advanced stages.