Scleroderma, also known medically as systemic sclerosis, is a clinical disease characterized by local or diffuse skin thickening and fibrosis that can affect the connective tissues of organs such as the heart, lungs, kidneys and digestive tract. The cause of the disease has not been fully understood to date and may be related to multiple causative factors. Some patients have a relationship with heredity and infection, while others develop the disease due to environmental factors. Many studies have shown that the occurrence of this disease has a greater relationship with autoimmunity. The disease can develop in various races throughout the country, there is no fixed population, can occur in all age groups and various occupations, but some data show that the incidence of women is higher than men, and the number of young people suffering from this disease is relatively high, but the disease is not contagious. The first is that the skin is not the only one that is not affected by the scleroderma, and the second is that the skin is not affected by the scleroderma. If patients with systemic scleroderma do not receive timely treatment or improper treatment, they may invade the heart, lungs and other internal organs, causing dysfunction of related organs and even endangering patients’ lives. There are many ways to treat scleroderma, such as medication, physical therapy, hydrotherapy, and surgery, but most of them can only provide relief, not cure. Surgical treatment is generally ineffective, the better effect is still the use of drug therapy. Immunosuppressants, adrenal corticosteroids, vitamins and other drugs can be used under the guidance of a doctor, and some drugs that activate blood circulation and improve blood circulation can also be used, which can help soften the skin.