The treatment of hepatocellular carcinoma still takes surgical resection as the first choice. Early resection is the key to improve the survival rate, and the smaller the tumor, the higher the five-year survival rate. Indications for surgery are: 1. clear diagnosis, estimated lesion is limited to one lobe or half liver; 2. no obvious jaundice, ascites or distant metastasis; 3. liver function is still well compensated, prothrombin time is not less than 50%; 4. heart, liver and kidney function tolerant. In those with normal liver function, the amount of liver resection should not exceed 70%; in those with moderate cirrhosis, it should not exceed 50%, or only the left half of the liver can be resected; in those with severe cirrhosis, lobectomy cannot be performed. Surgery and pathology confirm that more than 80% of liver cancers are combined with cirrhosis, and it is recognized that local resection instead of regular lobectomy has the same effect, while postoperative liver dysfunction is reduced and surgical mortality is also reduced. Since radical resection still has a high recurrence rate, it is advisable to review AFP and ultrasound imaging regularly after surgery to monitor recurrence. Because of the close follow-up after radical resection, small hepatocellular carcinoma with recurrence in the “subclinical stage” is often detected, and reoperation is preferred. Although liver transplantation is a treatment for liver cancer and has been widely reported abroad, its status in the treatment of liver cancer has not been confirmed for a long time. For developing countries, it is still difficult to promote it in recent years due to the source of donor and cost problems.