The saturation or concentration of uric acid in the body at 37°C is about 420μmol/L (7mg/dl) in men and 357μmol/L in women, and higher than this value is considered hyperuricemia. The main clinical drugs to lower uric acid are: 1. Drugs to promote uric acid excretion: The mechanism of such drugs is to inhibit the reabsorption of urate in the proximal renal tubules, thus increasing the excretion of uric acid and lowering the level of uric acid. It is suitable for people with good kidney function, and they should drink more water during the medication period, and it is recommended to take sodium bicarbonate 3~6g/d to maintain the suitable pH of urine, which is conducive to the dissolution and excretion of uric acid. Commonly used drugs are: benzbromarone, propofol. 2, drugs that inhibit uric acid production: the mechanism of these drugs is to reduce the production of uric acid by inhibiting xanthine oxidase, which is suitable for those who produce too much uric acid or are not suitable for using uric acid excreting drugs. Adverse effects should include gastrointestinal irritation, rash, fever, liver damage, bone marrow suppression, etc. The dosage should be reduced in patients with renal insufficiency, and is contraindicated in patients with renal insufficiency stage G5 (uremic phase). Allopurinol and febuxostat are the main drugs. 3, alkaline drugs: sodium bicarbonate can alkalize the urine, so that uric acid salts are not easy to gather in the urine to form crystals. It can maintain the urine PH value at 6.2~6.9. Adults take 3~6g/d orally. Long-term large amounts can cause metabolic alkalosis, and some patients may suffer from hypertension and edema due to high sodium load. 4.New uric acid-lowering drugs: ①Uric acid oxidase: decompose uric acid into soluble products for discharge; ②Selective uric acid reabsorption inhibitors. In addition, it is recommended to limit the consumption of alcohol and high purine food in daily life, drink water appropriately to increase the excretion of uric acid, and use drugs that inhibit uric acid excretion such as thiazide diuretics with caution; avoid triggering factors and actively treat diseases that cause high uric acid. Therefore, the main drugs to lower uric acid are the above, but the specific medication depends on the cause of the patient’s condition, and it is recommended to use the medication reasonably under the guidance of the doctor and adhere to the treatment to improve the treatment effect.