Liver transplantation is an important means of treating end-stage liver disease, and many patients with advanced liver disease need to receive liver transplantation: (1) Cirrhosis: Cirrhosis of various causes is an indication for liver transplantation, advanced cirrhosis is often combined with portal hypertension, ascites, jaundice or hepatic encephalopathy, and the traditional surgical or internal medicine means can not solve the fundamental problem of cirrhosis, and the patients’ quality of life is very poor, and only liver transplantation can Cirrhosis can only be cured by liver transplantation. Types of cirrhosis include: post-hepatitis cirrhosis, biliary cirrhosis, drug-induced cirrhosis, occult cirrhosis, and cirrhosis of other causes; (ii) chronic severe hepatitis: that is, often referred to as active hepatitis, liver transplantation combined with antiviral therapy can cure the hepatitis; (iii) fulminant hepatic failure: patients with acute viral or drug-induced hepatitis may quickly develop coma, severe jaundice, ascites, etc., that is, acute hepatic failure. , i.e., acute liver failure. This disease has a high mortality rate, and there is no good solution except liver transplantation; (d) liver tumors: benign tumors, including: 1, giant hepatic hemangioma, 2, polycystic liver, 3, other benign tumors of the liver; malignant tumors, including: 1, hepatocellular carcinoma, 2, cholangiocarcinoma, 3, other hepatic malignant tumors; (e) liver metabolic liver disease: 1, hepatomegaly, 2, glycogenosis, 3, other metabolic liver disease; (f) venous occlusive disease: patients with acute viral or drug hepatitis may quickly develop coma, jaundice, ascites and so on, that is, acute liver failure. (vi) veno-occlusive diseases: Buga syndrome, etc.; (vii) extensive intrahepatic bile duct stones; (viii) various other diseases that cause hepatic dysfunction. Children with the following diseases should also receive liver transplantation: i. Congenital biliary atresia; ii. Inborn metabolic disorders: 1, α1-antitrypsin deficiency 2, hepatomegaly 3, glycogen storage disease 4, hypertyrosinemia 5, other metabolic disorders; iii. Other diseases that require liver transplantation in adult patients.