Confinement phobia is when the patient is in a confined space, such as an elevator or an airplane, and feels fear, tension, dread, and has manifestations of autonomic dysfunction, such as panic, dyspnea, dizziness, headache, vomiting, abdominal pain, diarrhea, sweating, and shivering. The treatment of confinement phobia can be applied by a combination of medication and psychotherapy. In medication, when the patient’s symptoms are more severe and significantly affect daily life, antidepressants such as paroxetine and citalopram can be applied, and also short-term with anxiolytics. Cognitive therapy, behavioral therapy, psychoanalysis, family therapy and other psychological treatments along with medication can significantly improve the psychosocial factors that cause the occurrence of closet phobia, promote the recovery of the disease, and can prevent relapse.