More than 80% of alcohol is absorbed into the bloodstream through the stomach wall. When you eat other foods at the same time, alcohol enters the bloodstream in large quantities first. Therefore, drinking alcohol on an empty stomach is more likely to be drunk and more likely to hurt the brain. (1) Alcohol has deesterification and other effects, which can easily damage the gastric mucosa directly. (2) Alcohol directly or indirectly promotes the secretion of gastric acid. (3) Alcohol directly enters the blood vessels in the stomach and damages the endothelial cells of blood vessels in the stomach wall, causing bleeding. (4) It acts directly on the pyloric sphincter, causing pyloric closure malfunction and bile reflux. Therefore, drinking alcohol on an empty stomach or in large quantities is likely to cause damage to the gastric mucosa and gastric mucosal vessels, causing gastritis, erosion and bleeding or even ulcers. Alcohol and other absorbed nutrients have to be processed by the liver. Drinking alcohol on an empty stomach or in large quantities interferes with the liver’s energy metabolism and other functions, leading to liver dysfunction and causing serious cases: alcoholic fatty liver, alcoholic hepatitis, alcoholic cirrhosis and even liver cancer. So try not to drink alcohol on an empty stomach or in large quantities. Before drinking alcohol can be advanced to eat some easy to form a paste in the stomach easy to digest food or some easy to form a protective film in the stomach of drugs (bismuth or aluminum and magnesium preparations).