As the most common malignant tumor of the human female reproductive system, cervical cancer is the only malignant tumor that has a clear cause and can be prevented. In today’s world of cancer, the medical community has basically clarified that persistent infection with high-risk HPV is the cause of cervical cancer. Despite the increasing health knowledge, most people are still very unfamiliar with HPV infection, and some even keep this topic a secret. What is persistent high-risk HPV infection, and how much is it associated with cervical cancer? What should be done once HPV infection is diagnosed? Are there any effective ways to prevent HPV infection? I. What is HPV infection? HPV is human papillomavirus, and more than 130 types of HPV have been isolated, which can be classified into four types: skin low-risk, skin high-risk, mucosal low-risk and mucosal high-risk according to their invasive tissue sites. The mucosal high-risk types, especially HPV 16 and 18, are closely associated with cervical cancer in women. HPV is mainly transmitted through sexual contact, but may also be transmitted through close skin-to-skin contact. High-risk HPV infection may persist, which in turn causes abnormal cellular changes and eventually leads to cancer. II. Treatment of HPV infection? There is no specific drug treatment for HPV, in fact, there is no treatment drug for the virus, interferon and so on are to improve immunity rather than directly corresponding to the virus, you can consider immunotherapy, the purpose is to reduce recurrence and accelerate the removal of lesions, drugs: interferon, interleukin, thymidine, transfer factor, autologous vaccine and so on. In addition, some women may feel confused, fearful, upset, ashamed or even angry (perhaps blaming their spouse or partner) if they are found to be infected with HPV or have cervical cancer caused by HPV. All these emotions are understandable. Therefore, the necessary psychological guidance is very helpful for the treatment of the disease. HPV infection is not equal to cervical cancer and there is no need to talk about the virus: In most cases, HPV infection can be completely cleared by the body’s own immune system. The Centers for Disease Control and Prevention (CDC) found that 70 percent of newly infected HPV patients can clear the virus within one year, and 91 percent of infected patients will clear the virus within two years. Only when high-risk HPV remains viable do cells that have undergone abnormal changes have a chance to progress to cervical cancer. Overall, women with persistent high-risk HPV infection are 200 times more likely to develop cervical cancer compared to women who are not infected. It takes about 10 years for HPV infection to develop into invasive cancer, but regular gynecological checkups can prevent cervical cancer by detecting precancerous lesions early and treating them. Therefore, women do not need to talk about toxicity. Therefore, there is no need for women to talk about the virus, HPV infection is not equal to cervical cancer, and there is no need to remove the uterus for this reason. However, it is recommended that patients infected with HPV should have annual HPV and cervical cytology examinations for early detection and treatment of cervical cancer. After all, besides life, women also want to keep their normal functions, and early treatment with less damage can completely not affect their lives. 4. Good prevention and follow-up – for reproductive health: At present, cervical cancer is the only cancer among all human cancers that has a clear cause and is treatable with early detection, and its 5-year survival rate for early treatment is close to 100%, while the 5-year survival rate for late treatment is 20-50%. Screening is currently the main tool for prevention and early diagnosis of cervical cancer. All obstetrics and gynecology societies around the world recommend HPV testing for early screening of cervical cancer for effective surveillance and early detection of cervical cancer. The current follow-up methods include: visual observation with a vaginal speculum, cervical smear (TCT), colposcopy (biopsy pathology if necessary), and HPVDNA testing. Avoiding HPV infection is the most natural prevention method to protect women from cervical cancer. The HPV vaccine currently and in the coming years will be produced only for the preventive work of the virus. Currently, it only targets 16 and 18 high-risk oncogenic HPV infections and is limited in the types of viruses it can prevent, and there is still a chance of infection with other high-risk oncogenic viruses. And the effectiveness of HPV vaccine prevention remains to be observed in the longer term. In conclusion, HPV infection should be taken seriously but not overly feared. In our daily life, we can prevent and reduce HPV infection by the following points: 1. strengthen exercise, healthy diet, and improve the body’s immunity. 2. 2. Regular follow-up, regular cytology and colposcopy. Women who have sex should be tested for HPV-DNA. 3. use condoms. a 2002 meta-analysis showed that although condoms did not prevent the risk of HPV infection, the risk of genital warts, high-grade intraepithelial neoplasia of the cervix, and cervical invasive cancer was reduced.