According to “Qianjiang Evening News” reported, Xinjiang people Ms. Li driving tour from Tibet back suffered from severe headache disease, this headache is also very strange to say: “stand up on the headache to tears, lying down feeling better.” Subsequently, she was diagnosed by the hospital as spontaneous intracranial low pressure, because there is a fissure in the spine, the brain inside the “water” leak out resulting in headache. The typical symptom of intracranial low pressure syndrome is headache when standing or sitting, and relief when lying down.” The main manifestation symptom of intracranial low pressure syndrome is headache, and there is an obvious relationship between headache and position change. When sitting up or standing, the headache is severe, and when lying down, it disappears or relieves quickly, and the patient is forced to lie down in bed. At the same time, it is often accompanied by nausea, vomiting, dizziness or vertigo, photophobia, tinnitus, anorexia, fatigue, insomnia, emotional instability, transient syncope and mental retardation. What exactly is the cause of intracranial low pressure syndrome? This water flow is like a protective buffer to avoid direct contact between the brain and the skull, and the delicate brain tissue “floats” on this water inside the skull. The cerebrospinal fluid is constantly produced and absorbed, and the daily secretion is no more and no less than 150 ml of cerebrospinal fluid is produced in the adult brain every day. When the water is gone one day, the “buoyancy” disappears, and when people stand, due to gravity, the brain tissue is out of balance or even attached to the inner wall of the skull, the human feeling is a headache, if not treated in time, brain tissue may occur because of the “pulling” effect of cerebral hemorrhage, which can be fatal in severe cases. In serious cases, it can be fatal. 2, “water leakage” is common in lumbar puncture “In general, this disease is accompanied by the experience of lumbar puncture patients, but also spontaneous intracranial low pressure.” Making the loss of cerebrospinal fluid is the most common cause of intracranial low pressure syndrome and is its main pathogenesis. It is most often seen after lumbar puncture, after traumatic obstructive hydrocephalus shunts, meningitis and the release of large amounts of cerebrospinal fluid during cranial or spinal surgery. Since lumbar puncture is a common cause of intracranial low pressure syndrome, the operation of lumbar puncture should be standardized by using a fine needle, keeping the patient in a position to avoid movement during the puncture, and keeping her lying down with the pillow removed after the puncture. Ms. Li’s headache originated from spontaneous intracranial low pressure, which is a relatively rare condition, mainly due to a fissure in her spine from which cerebrospinal fluid leaks out. In addition to symptomatic treatment, i.e., finding the cause, symptomatic treatment is mainly lying down and supplementing saline, and generally, the prognosis is good.