The symptoms of glucocorticoid osteoporosis are insidious and atypical, mainly manifesting as back pain, weakness, limb twitching or difficulty in movement; in severe cases, bone pain and non-violent fractures occur, with fracture sites mostly in the spine, hip, wrist and rib cage; patients with glucocorticoid osteoporosis have a higher risk of fracture than postmenopausal women; the main signs include shortening of height and spinal deformation. Treatment strategy: (specific treatment needs to be considered individually, please follow the doctor’s advice during consultation) 1. Basic treatment: Calcium: 1200-1500 mg/d; Vitamin D: 800-1000 IU/d. 2. Anti-osteoporosis treatment: Bisphosphonates, sex hormone replacement therapy, calcitonin, parathyroid hormone, Chinese herbal medicine, etc. 3.Glucocorticoid therapy: no safe dose, consider calcium and vitamin D base therapy at the beginning