Infrared spectroscopy is also known as infrared spectrophotometry. Infrared spectroscopy is the “fingerprint” of a substance, and its detection principle is based on the characteristics of the absorption peaks in the infrared region of the sample to determine the structure and composition of the compound. As early as 1955, infrared spectroscopy has been used abroad to study and determine the composition of stones. Infrared spectroscopy has many advantages: it is accurate, fast and convenient; it can analyze both crystalline and non-crystalline components; it can analyze both organic and inorganic compounds. Therefore, with the improvement of infrared spectroscopy technology and the significant reduction of equipment cost, it has been the main means to analyze stone composition since 1980s abroad. Features of Infrared Spectral Analysis System Infrared spectral analysis is the process of identifying the composition of analytes (stones) based on the peak position, peak intensity and peak shape in the spectrum. Since there are more than 30 kinds of stone components, and there are many mixed components, the analysis of the spectrum is very tedious, not easy to grasp, and easy to make mistakes, which affects its promotion and use in clinical medical profession. In response to this technical problem, scientists have developed automatic stone infrared spectroscopy analysis systems (such as TENSOR27/37 series from Bruker, Germany, and the automatic stone infrared spectroscopy analysis system developed by Professor Sun Xizhao (the presiding researcher) and BlueMode, Nanjing Gulou Hospital. The analysis system has two major features: the process of resolving the spectrum is completely automated; the accuracy of identification is higher than that of manual analysis. This innovative technology has successfully solved the current challenges of modern analysis of stones and can fundamentally replace the old chemical analysis, which will undoubtedly have a profound impact on the standardization of diagnosis and treatment of urolithiasis. Urolithiasis is one of the three major diseases of urology. Because it is a lifelong disease, the recurrence rate is high, varying with stone composition, in untreated patients, and with stone composition, in untreated patients, the recurrence rate is as high as 50% to 100%, while in patients receiving control, the recurrence rate can be reduced to 10% to 15%. Therefore, prevention of stone recurrence is crucial. Stone composition analysis is a method to determine the nature of stones. Diagnostically, it provides direct evidence to discriminate the etiology of non-calcium stones and, in the case of calcium stones, helps to narrow the scope of the metabolic assessment of stones; therapeutically, it is an important basis for the development of stone prevention programs and the selection of lithotripsy therapy, and is therefore a prerequisite for the individualized treatment of patients with urolithiasis (Figure attached). Stone specimens can be obtained by surgery, lithotripsy and self-discharge. Analysis of stone composition includes both qualitative and quantitative analysis, and usually qualitative analysis is sufficient to meet clinical needs. Methods of stone analysis include chemical and physical methods. The main disadvantage of the chemical method is the high volume of specimens required, about 100 mg. Today, since most of the stone specimens come from the powder excreted by the patient after shock wave lithotripsy, the volume of specimens is generally small, which makes it difficult to meet the chemical analysis method in most foreign countries has been eliminated and is occasionally used as an adjunctive analysis. Infrared spectroscopy is a commonly used physical analysis method, which is much more accurate than chemical analysis and requires only 1 mg of specimen.