In clinical practice, we often see many patients with more or less residual symptoms after antidepressant treatment, whether in those who have partially responded to antidepressants or in those who are effective or clinically cured according to current assessment criteria. The prognostic impact of the presence of residual symptoms is multifaceted and includes relapse, relapse, impairment of work capacity, and pessimistic mood. In the current scale, we consider a patient to be clinically cured when he or she has a score of Q7 on the 17-item HAMD scale. However, most data do not tell us what residuals are actually included at the R7 score. What are the residual symptoms? How much more time is needed to treat and what treatments are needed for these residual symptoms to disappear? What is the link between residual symptoms and the adverse effects of antidepressants? What is the relationship with relapse and relapse? In a longitudinal study, PAVKEL [1] found that 75% of 64 patients with major depression who had a partial response to treatment (with a HAMD score of 8-18) had residual symptoms, mostly fatigue, somatic and psychogenic anxiety, sleep disturbance, sexual dysfunction, and depressed mood. More than half of the patients present with sleep disturbances and feelings of guilt and guilt. NIERENBERG [3] similarly found in patients clinically cured by antidepressant treatment (HAMD score Q7)