Midlife is one of the most important periods of life. We often compare middle-aged women in menopause to roses, each with a different life situation, and a different state of being. Caring for menopause is like a gardener to a flower or plant. Watering, fertilizing and pruning are all essential. Among them, medication for menopause is essential for women who experience menopausal symptoms. However, in practice, some women who have the need for sex hormone replacement therapy end up abandoning it for various reasons. One of the more common reasons is that they become unwell after taking the medication for a short period of time and discontinue it. Here we analyze the problems and reveal the mystery. Since puberty, women’s gonads are in full bloom, secreting sufficient amounts of sex hormones to maintain menstruation, pregnancy, and other physiological functions. The most important of these hormones is estrogen. After menopause, as the ovaries are the first organ to age and fail, the level of sex hormones decreases sharply, with plasma estrogen levels of only 10-20 pg/ml, often leading to a series of clinical symptoms. And at this time, appropriate amount of estrogen supplementation is obviously an effective treatment. Overall, it is also supposed to be safe to supplement what is lacking. However, in actual treatment, how much, what and how to supplement can really vary for each woman. The various discomforts of menopause stem from the dramatic decline in sex hormones, but also because sex hormones are among the chemicals most extensively connected to the tissues and organs of the body. There are more than 400 tissues and organs in the body that have related sex hormone receptors, so its increase or decrease can affect the body’s functions in an extremely wide range of ways. This is further supported by the diverse and widespread symptom clusters that manifest during menopause. The various discomforts of menopause can run into dozens. Similarly, during menopause, when the body’s hormones decline rapidly and estrogen is supplemented through medical intervention, it is only natural that each individual will respond differently. To reduce such uncomfortable reactions, estrogen is often supplemented with the lowest effective dose that will relieve symptoms, rather than supplementing to the 200 to 300 pg/ml level of puberty. Even then, for specific different individuals, exactly how much supplementation will both achieve therapeutic goals and reduce discomfort sometimes requires gradual adjustment by the physician. On the other hand, the sex hormone drugs currently in medical use are steroid hormones with the chemical structure of cyclopentane polyhydrophenanthrene, mostly synthetic analogs or extracted from nature. The various drugs show different properties mainly due to the differences in their respective side chains, and thus different advantages and side effects. Together with the same principles mentioned above, these drugs also bind to human tissues as extensively as natural estrogens, which in turn can cause different biological effects and lead to different manifestations. Among them, it is possible that they may cause different discomfort reactions depending on individual tolerance. From the above analysis, it is clear that sex hormone replacement therapy is indeed needed for those who experience more obvious menopausal symptoms, especially those that affect their work and life. In sex hormone replacement therapy, various biological effects are induced by the extensive combination of the body with estrogen and similarly structured replacement drugs. Some of these effects change the pathological state of the body and play a therapeutic role, while others are unwanted and cannot be solved by modern medicine for the time being, which are often referred to as “side effects”. Among these side effects, some recent discomfort after taking the drug is the issue we are discussing today. These discomforts need to be reported to the physician, who can promptly propose countermeasures and even adjust the drug regimen to solve the problem. It should not be a reason for patients to give up treatment. In this regard, we often have a graphic analogy. As a creature of nature, human beings undergo various physiological changes that are ordained by the Creator, i.e. “God”. This includes the physiological changes that occur during menopause. However, to a certain extent, human beings can make moderate adjustments in harmony with nature for the benefit of human health and happiness. Because of this, in the process of reconciliation with nature, human beings cannot do anything brutal, but need to “negotiate with God”. Therefore, we liken the recent discomfort in estrogen replacement therapy to a “reminder from God”, which is a kind consultation. Such a reminder is a language that the doctor can understand. As long as the person taking the medication works closely with the doctor and makes adjustments based on evidence, he or she will eventually find a medication plan that suits him or her. Life in middle age is like a rose in all its beauty, while menopause without care is like a fading rose, and all that remains is thorns. Women in menopause should indeed take care of themselves, including accepting the findings of modern medicine to perfect their lives. Human beings are perfected in harmony with nature, and nature is sublimated in human perfection. To take care of one’s life and to watch over menopause is to sublimate in harmony with nature to the process of constant perfection and happiness. May every woman in menopause be happy, perfect and blissful.