Normal values of estradiol vary with the female cycle and differ in women during the 4 phases of prepubertal, follicular, ovulatory and luteal phases. Estradiol is a steroid hormone that promotes the transformation of the endometrium into a proliferative phase in order to promote the development of female secondary sexual characteristics, enhance the contraction of the smooth muscle of the uterus, promote the development of breast ducts and contribute to the proliferation of the endometrium. You can check sex hormone 6 on the 2nd day of menstruation to clarify the level of estrogen. If estradiol level is lower than normal, it means that women have some problems with hormone secretion from the ovaries and may have premature ovarian failure. Low estradiol can cause dry and wrinkled skin, shrinkage of breasts, and affect ovarian function, leading to non-ovulation and affecting fertility. So once the estradiol level is low, it will have a great impact on women’s bodies, usually pay attention to rest, do not stay up late, do not blindly use drugs, timely gynecological examination at the hospital to determine the cause of the disease, and then the right treatment. The actual body will be able to be more active during the day to enhance the immune system.