Overuse of the brain can cause headache, mainly due to lack of oxygen in the brain. In severe cases, patients may experience memory loss, inattention and disordered thinking. It is important to use the brain rationally and rest properly, and if necessary, oral medications to improve brain metabolism, such as olanzapine, piracetam and cytarabine, can be taken. Headache is a symptom that can be caused by a variety of reasons, for example, patients with insufficient blood supply to the brain may cause ischemia and hypoxia in the brain, which can cause hypoxic encephalopathy, and patients can experience the above symptoms. If the patient has hypertension, it may cause hypertensive encephalopathy, which in severe cases may cause increased intracranial pressure, and the patient may also experience headache, as well as nausea and vomiting. It may also be caused by cervical spondylosis. Patients with cervical spondylosis have headaches, which generally manifest as pain in the back of the head, and may also be accompanied by discomfort and soreness in the neck muscles, or pain at the top of the head. In addition, we should rule out intracranial organic lesions, and we should check the cranial MRI to clarify the diagnosis. In conclusion, a comprehensive analysis of the causes of headache should be conducted.