Chalazion, also known as a chalazion cyst, is a chronic granulomatous inflammation of the lid gland caused by obstruction of the lid gland outlet and retention of secretions. It is a slow-onset, palpable nodule on the surface of the eyelid with no pressure pain and a purplish or gray-red elevation on the conjunctival surface of the corresponding lid, which can occur singly or in multiple locations simultaneously or sequentially. Small, asymptomatic cases can be observed without treatment, while larger ones or those with granulation should be surgically removed. Macroglossia is an acute inflammation of the lid gland caused by a bacterial (usually staphylococcal) infection and has the characteristics of an acute inflammatory disease, namely redness, swelling, and pain. Treatment is also local and systemic antibiotic therapy for the inflammation. When an abscess is present, local incision and drainage of the pus is required. Sometimes, chalazion is secondary to infection, which can confuse the two conditions. When a localized painless mass remains on the eyelid after the inflammation subsides, surgical treatment is still required. This is why surgery is also required with anti-inflammatory medication.