1, end-stage cirrhosis of various causes 2, acute or chronic liver failure 3, primary biliary cirrhosis 4, hepatic sinusoidal nucleus degeneration (Wilson’s disease) 5, primary or secondary sclerosing cholangitis 6, severe alcoholic cirrhosis who have abstained from alcohol for more than six months 7, polycystic liver with liver failure 8, primary or secondary biliary cirrhosis combined with liver failure 9. Budi-Chiari syndrome with liver failure 10. primary liver tumor 11. congenital metabolic diseases 12. congenital biliary atresia in children 13. familial biliary depression 14. congenital fibrotic diseases The above liver diseases, which have progressed to the following levels, require immediate liver transplantation: (1) progressive deterioration without other effective treatment End-state liver disease. (2) Certain primary hepatobiliary tumors for which liver transplantation is the only possible cure. (3) Recurrent gastrointestinal hemorrhage due to rupture of esophageal varices without liver failure and when treatment is ineffective. (4) Those with end-stage cirrhosis who have a severely poor quality of life and require long-term repeated hospitalization – those who are hospital dependent.