Life science is one of the most rapidly developing disciplines in the 20th century and has become the most remarkable field in natural science, among which the research on stemcells has been a hot topic in recent years. The study of stem cells can help human beings understand the basic laws of life, such as growth, differentiation and developmental mechanism of organisms, and is of great significance to biology and human life and health. In late 1999, the journal Science published a list of the top ten scientific achievements. Stem cells are part of the undifferentiated primordial cells collectively preserved during evolutionary adaptation and characterized by self-renewal ability and multi-directional differentiation potential. These cells are found in embryonic, called EmbryonicStemcell, and mature tissues, called SsmaticStimcell. Recent studies have shown that stem cells are commonly found in tissues and organs of adult animals and play a key role in their repair and regeneration after injury, and offer the possibility of using adult stem cells for the treatment of diseases. In situ liver transplantation is currently the most ideal treatment for end-stage liver disease, but the lack of donors, high cost of surgery and long-term use of immunosuppressive drugs have hindered its promotion. Stem cell research has now made impressive achievements in the medical field and has provided new ideas for the treatment of end-stage liver disease. Bone marrow stem cells can differentiate laterally into stem cells without cell fusion and into fully functional stem cells after differentiation, and Crosby et al. detected that stem cells can differentiate into oval cells, hepatocytes, and bile duct cells using immunofluorescent labeling after clinical bone marrow transplantation. The application of bone marrow stem cells for disease treatment has many advantages over traditional methods: easy to obtain material, easy to culture, pass on and expand in vitro, directly from the patient himself, high safety, no allogeneic rejection, and avoiding the ethical controversy of embryonic liver cell research, so the clinical application is very promising. Because of the strong plasticity of bone marrow stem cells, they may be “recruited” to participate in the regeneration of distant tissues under physiological or pathological conditions, but this “spontaneous” “recruitment” is weak. However, this “spontaneous” “recruitment” is weak, and it has been thought to “drive” bone marrow stem cells into the peripheral blood with bone marrow stem cell mobilizers, thus allowing the peripheral blood stem cells to receive therapeutic quantities, using hepatocytes to “spontaneously” “homing” to the injured tissue and The “homing” of hepatocytes to the damaged tissue and their differentiation into damaged tissue cells under the action of specific tissue as environment can achieve the effect of repairing ischemic injury. At present, the mobilizing agents approved for use with bone marrow stem cell mobilization internationally include stem cell factor and granulocyte-macrophage colony-stimulating factor. In 2001, Wright et al. found that bone marrow stem cells not only existed in large numbers in the bone marrow, but also some of them entered the peripheral blood circulation and migrated actively between the bone marrow and peripheral blood by constructing a pair of conjoined mice sharing a common set of circulation. In addition, the number of stem cells in the peripheral circulation can be significantly increased under the effect of emergency, injury and drugs (e.g. stem cell mobilization), which may be aimed at promoting tissue repair. Granulocytecolony-stimulating factor (G-CSF) was used to mobilize stem cells in a model of myocardial infarction, and it was found that the mobilizing agent increased the number of peripheral blood stem cells by 250 times the normal amount. At the same time, it has been shown that stem cells have the property of migrating to the injured tissue, i.e., homing, which Helmuth called “stem cells hear the call of the injured tissue”. The presence of inflammatory response to tissue injury and the expression of various chemokines such as interleukin-8, monocyte chemotactic protein and tumor necrosis factor, as well as the upregulation of the expression of various adhesion molecules in vascular endothelial cells and other changes in the microenvironment may be the initiating factors for stem cell homing. increase in number? Currently, there are more reports on the application of bone marrow stem cells for treatment in the field of myocardial infarction in China and abroad. Previous studies have suggested that bone marrow stem cells can migrate to the damaged site in Sydney after myocardial infarction and differentiate into Sydney cell nuclei Xu coronary endothelial cells in the cardiac environment to participate in the regeneration of necrotic attack tissue. However, a study by Field et al. at the University of Washington Her Stanford University School of Medicine Balasm et al. concluded that bone marrow stem cells ultimately cannot differentiate into new heart trace cells, but can promote neovascularization of damaged tissues, from which patients with myocardial infarction may benefit. In contrast, vascular endothelial progenitor cells (EPC) are the entire population of mature vascular endothelial cells, which belong to the stem cell population. Some scholars have isolated endothelial progenitor cells from bone marrow and external first blood, and in vitro induced differentiation can express antigens characteristic of endothelial cells, suggesting that endothelial progenitor cells exist not only in the village and bone marrow, but also in peripheral blood. In animal experiments, it has been demonstrated that EPCs that have been cultured and expanded in vitro can effectively enhance vascular regeneration and collateral circulation in ischemic tissues. From this, we envision that bone marrow stem cell mobilization, which also includes the promotion of vascular endothelial progenitor cells, i.e., it is possible to promote vascular repair or vascular regeneration in damaged liver tissue and further prevent liver fibrosis and improve liver function.