How long can a blister on the lips heal itself if it is not picked depends on the condition and treatment method, and cannot be generalized. The most common is herpes labialis caused by herpes simplex virus infection, which is a viral skin disease and is highly contagious. If the patient has mild symptoms and no secondary infections, most of them do not require treatment and can usually heal in about 1 week without picking the blisters. If the patient is seriously ill, he or she should usually not wait for it to disappear on its own and should be treated by aspirating the fluid inside with a sterile syringe and disinfecting it with iodophor. At the same time, antiviral treatment should be actively carried out, and acyclovir ointment or neomycin ointment is often applied directly to the affected area, and vitamin C and vitamin B2 are taken orally to complement the treatment. Since blisters on lips mostly occur when the immunity is low, patients are advised to improve the body resistance appropriately. In addition, if the blisters do not recover after 1 week, it is recommended to visit the dermatology department of the hospital for standardized diagnosis and treatment.