Herpes simplex virus is one of the most aggressive viruses in humans, but only a fraction of people develop it clinically. The disease can be classified as: herpes simplex of the mouth and lips, herpetic keratitis, herpes pubis, Kaposi’s disease, etc. It is sometimes the cause of meningitis and encephalitis. It has two types, type 1 and type 2. type 1 is mainly acquired from orofacial lesions, while type 2 can be isolated from genital lesions. Herpes simplex virus is widely distributed worldwide and infection is extremely common in the population, with a high number of latent and recurrent infections. Patients and carriers are the infectious agents of the disease. The virus can enter the organism through direct contact with skin and mucous membranes or through sexual contact. Type 1: The infection is often confined to the perioral skin or the pharynx, and gingivostomatitis clinically manifests as herpes on the gums and cheeks, fever, sore throat, and ulcers upon rupture. It can also cause encephalitis. In adults, it can cause pharyngitis and tonsillitis. The virus is latent in the trigeminal ganglion. Type 2: The infection primarily causes genital herpes, which manifests as blistering ulcerative damage to the penis in men and blistering ulcerative damage to the cervix, vulva, and vagina in women, with complications including extragenital injury and aseptic meningitis. The duration of disease is approximately 3 weeks. The virus is latent in the sacral ganglia. Patients with herpes virus should seek early diagnosis and aggressive treatment from a physician.