The sudden appearance of a bunch of small clear blisters on the lips is mostly considered as oral and labial herpes, which usually recovers in 7-10 days. Oral and labial herpes is caused by herpes simplex virus infection, which is a contagious disease. It tends to recur when the immune system is weakened due to excessive fatigue, smoking and drinking, cold and cold, spicy and stimulating foods, etc. The course of the disease is usually 7-10 days. If the blisters are not particularly large and do not affect normal life, no treatment is needed and the patient can usually recover within the course of the disease. If the blisters are large and affect the patient’s life, the patient needs to be treated with topical acyclovir ointment and oral acyclovir tablets and thymidine enteric-coated tablets. In addition, patients should pay attention to a light diet during the disease, do not eat spicy and stimulating, greasy food, as well as rest on time, do not stay up late, appropriate physical exercise, pay attention to keep warm, avoid cold stimulation, prevent colds.