The main points of rescue and treatment of organophosphorus poisoning are summarized as follows: a. A core. Take cholinesterase activity as the core. Two major points. To reduce drug absorption and removal of absorbed drugs as the focus. Three core techniques. Including gastric lavage technology, mechanical ventilation technology, blood purification technology. Four major goals: 1) to restore cholinesterase activity to more than 40%; 2) to achieve “atropinization” and inhibit acetylcholine toxicity; 3) to prevent intermediate syndrome by early and adequate application of dephosphoridine; 4) to prevent aspiration pneumonia and toxic encephalopathy.