Hepatobiliary stones with obvious clinical symptoms require treatment. There is no consensus on the need to treat stationary stones that are asymptomatic. In view of the fact that with the evolution of the disease and the development of lesions, most cases will have obvious symptoms and the possibility of malignant transformation of the affected hepatic ducts, most experts advocate active surgical treatment or percutaneous transhepatic choledochoscopic stone extraction for stationary stones. Hepatobiliary stones are mainly treated by surgery, the principle is to remove the lesion, remove all the stones, correct the stenosis, smooth drainage and prevent recurrence. There are various surgical and non-surgical treatments for the complex intra- and extra-hepatic bile ducts and liver lesions of hepatobiliary stone disease. According to the number and distribution range of intra-hepatic bile duct stones, the location and degree of hepatic ductal stenosis, pathological changes in the liver, functional status of the liver, and the patient’s systemic condition, an individualized treatment plan should be formulated for the specific case and an appropriate surgical method should be selected. There are four main surgical methods: (1) choledochotomy and lithotripsy; (2) partial hepatectomy; (3) repair and reconstruction of portal bile duct stenosis; and (4) liver transplantation. With the continuous improvement of laparoscopic surgery technology and the gradual improvement of surgical instruments, choledochotomy and partial hepatectomy can be accomplished by laparoscopic surgery, which can be accomplished by inserting surgical instruments into the abdominal cavity through 3-5 small holes of 0.5-1.0 cm in the abdominal wall. Because of the avoidance of the “big incision”, the damage to the abdominal wall is extremely small, with the advantages of small trauma and fast recovery. In addition, the application of intraoperative ultrasound, cholangiography and choledochoscope plays a very important role in adopting the correct surgical method. Intraoperative ultrasound: It can clearly determine the distribution of stones in the liver, guide the extraction of stones, and significantly reduce the residual stone rate. It can also show the relationship between the important blood vessels in and out of the liver and the lesion, determine the scope of the lesion, and thus guide hepatic resection. Intraoperative cholangiography: It plays an important role in understanding whether there is any variation in the biliary system, avoiding bile duct injury and preventing and controlling the retention of stones in the bile duct. Intraoperative cholangioscopy: It is one of the most important methods for the treatment of hepatic and biliary stones, which can clearly visualize the pathological conditions in the bile ducts, identify bile duct stones, tumors, and foreign bodies, observe the lesions of the biliary mucosa, and take biopsies or exfoliated cells of suspected lesions to do pathological examination. Microscopic stone extraction with mesh basket, lithotripsy instruments and balloon catheter overcomes the blind spot of conventional instruments, improves the efficiency of stone extraction and reduces the rate of stone retention. For cases of intraoperative stone retention, the residual stones in the hepatobiliary duct can be removed after surgery by entering the bile duct through the T-tube sinusoidal tract, biliary fistula tract, or subcutaneously embedded blind loop of the bile duct jejunoileal anastomosis. Recurrent stones can be removed by choledochoscopy through a subcutaneous blind loop. Endoscopic stone extraction by percutaneous hepatic puncture is also an effective treatment for recurrent stones. Individualized minimally invasive treatment of hepatic and biliary stones with laparoscopy, choledochoscopy and duodenoscopy: laparoscopy and choledochoscopy are minimally invasive treatments for hepatic and biliary stones without incision, with small trauma, fast recovery, and more than 99% of stone removal; for the old and weak hepatic and biliary stone patients who can’t tolerate the surgery, the duodenoscopes can be used to remove the stones from the common bile ducts to alleviate the symptoms and to improve the quality of life for the patients if they have stones that block the common bile ducts. Quality of life of the patients.