Syphilis eradication mainly requires early diagnosis, timely treatment, adequate dosage of medication, and a standardized course of treatment. For early syphilis, adequate dosage of penicillin can achieve the effect of eradication. For those who are allergic to penicillin, tetracycline, doxycycline or erythromycin can be used. For advanced syphilis, in addition to using penicillin in sufficient quantity, it is necessary to control the damage of internal organs, such as treating heart failure and controlling neurological symptoms. For penicillin allergy, again switch to tetracycline, doxycycline, or erythromycin.