Recently, the author performed a large case of minimally invasive resection of focal hepatic nodular hyperplasia. After careful preparation and using fine anatomical techniques, the large liver tumor was successfully removed. Due to the delicate surgery, small trauma, minimal bleeding during the surgery, and the normal liver was little affected, there were no complications after the surgery, and the patient recovered rapidly and was discharged from the hospital in less than seven days. Huang Gang, Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Guangzhou Medical University The details are as follows: Patient Peng Moumou, female, 24 years old. She was admitted to the hospital in March 2013 due to “vague pain and abdominal distension in the upper abdomen for 3 months”. The patient began to experience vague pain and distension in the upper abdomen 3 months ago, but had no other symptoms. He was admitted to the hospital with normal vital signs, no yellowish sclera and no enlargement of superficial lymph nodes. The right mid-upper abdomen was slightly bulging, no liver or mass was palpated, no pressure pain, and no buckling pain. After routine preoperative examination, the patient was admitted to the hospital and decided to undergo less invasive laparoscopic (minimally invasive) liver tumor resection, which was performed soon. Through fine dissection and separation, the operation was very smooth and complete resection of the larger liver tumor was performed. The patient recovered well after the operation without any complications, and the patient ate a liquid diet etc. on the first day after the operation. The patient recovered well after surgery without any complications and ate a liquid diet on the first day after surgery. Since the blood supply to the hepatic hilum was not blocked during the surgery and the dissection was precise, the liver function was also minimally affected and the patient recovered quickly. The patient was discharged from the hospital less than seven days after surgery. All postoperative follow-ups were normal. Minimally invasive liver tumor resection has the advantages of small incision, less surgical trauma, less bleeding, fast postoperative recovery, small and hidden abdominal scars, and does not affect the aesthetics, etc. It is suitable for men, women and children, especially for those who have high demands on abdominal aesthetics. Minimally invasive liver resection requires a high level of skill from the surgeon, which must be performed on the basis of skilled open abdominal surgery techniques, and the surgeon must have the comprehensive ability of composure, calmness, carefulness, dexterity and comprehensive skills to complete it. Otherwise, a rough action can cause irreparable consequences.