Slow plus acute liver failure, firstly the time concept is about 2 weeks to half a year, secondly the clinical manifestations caused are also severe gastrointestinal symptoms, with weakness, nausea, poor appetite. There are other PTA is also less than 40%, jaundice > 171μmol/L, or jaundice will rise to 17.1μmol/L per day, some clinical manifestations of hepatic encephalopathy. Generally speaking if you have slow plus acute liver failure is more critical, especially when the PTA <20% or less, hepatocyte necrosis in large numbers, the disease will be very serious, so this disease depends on the general condition of the patient, such as the synthesis of the liver, like the methemoglobin situation, and cholinesterase, and whether the jaundice is a rapid regeneration, there is no co-infection. Generally speaking, the treatment effect is relatively good without reaching PTA <20%.