What are the common causes of acute liver failure? Acute liver failure is often liver damage that occurs during the course of acute or chronic liver disease, acute poisoning or combined organ failure of other systems, with a very aggressive prognosis and a high mortality rate. The more common causes are as follows: 1, when serious trauma occurs in the body, due to the acute stress reaction, the body hormone level disorder, can cause multi-organ failure induced by acute liver failure. 2, patients with severe infection, shock and other conditions, the body of a large number of toxins through the liver metabolism to increase the burden on the liver, damage to liver cells caused by the occurrence of acute liver failure. 3, cirrhosis decompensated patients with serious damage to liver cells will induce liver failure, patients will appear a large amount of ascites, bilirubin is elevated, transaminases normal or even decreased these are the manifestations of liver failure. 4. Patients with obstructive jaundice are often unable to discharge a large amount of bile, which leads to massive necrosis of hepatocytes and causes the occurrence of acute liver failure. 5. Patients who have undergone extensive liver resection for liver tumors or portal vein shunts for portal hypertension often have acute liver failure due to severe hepatocellular damage. 6. Other causes such as chemical poisoning and viral hepatitis may also cause acute liver failure.