What is the treatment and prognosis of liver failure? As we all know, liver failure is often caused by severe trauma, shock, infection, extensive hepatectomy, portal vein shunt, viral hepatitis, cirrhosis, chemical poisoning, etc. Therefore, the rate of death from liver failure is very high, so we should try to control the progress of liver function damage and prevent the common diseases and causes that trigger liver failure. First of all, drugs are toxic, so we must pay attention to the adverse effects of drugs on the liver when using any medication. Patients with combined hepatic insufficiency should be cautious in the use of drugs that can damage the liver. Secondly, when performing invasive surgery, a comprehensive and scientific preoperative evaluation of the patient should be performed, especially to fully understand the liver function. In particular, the preoperative presence of liver insufficiency must be corrected in patients with previous comorbidities such as cirrhosis, hepatitis, jaundice, and hypoproteinemia. Finally, avoid the use of hepatotoxic drugs in anesthesia, and try to prevent hypoxia, hypotension, shock, and infection during and after surgery to avoid damage to hepatocytes. Postoperatively, we should maintain good respiratory circulation, strengthen anti-infection and maintain nutritional metabolism. We know that liver failure is a very serious disease, once it occurs, it is often difficult to completely cure, and the death rate of patients is very high. However, as long as we usually strengthen the awareness of liver protection and timely treatment of liver function abnormalities, we can avoid the occurrence of liver failure as much as possible.