Liver failure (severe hepatitis), which is a serious disease with a high mortality rate. The pathogenesis is complex and not yet fully understood, but the consensus conclusion is that it is the result of viral replication, its protein antigens and the host immune response. The abnormal host immune response caused by the hepatitis virus (but also by other causes such as drugs, toxins, blood clots, etc.) under certain conditions is probably the main link in the pathogenesis of severe hepatitis, which is based on massive necrosis of hepatocytes leading to liver failure and the resulting endotoxemia that further deteriorates liver function and leads to the death of the host. Patients are often admitted to our clinic having missed the host immune response phase (a phase in which there are specific treatments to block progression) and have reached the stage of massive hepatocellular necrosis. Treatment during this phase is focused on controlling endotoxemia. The patient’s deteriorating condition is often due to an underlying infection that is not controlled. Therefore, the first task in the treatment of severe hepatitis is to determine the possibility of infection, and aggressive control of infection is the key to treatment.