The liver is the biochemical synthesis “processing plant” that ensures the normal supply of healthy blood to the body. As an important organ of the body, its health is not only directly related to the “success or failure” of the “processing plant” itself, but also affects the “survival” of other organs of the body. Once the liver is attacked by viruses, alcohol, drugs and other harmful factors, the infrastructure of this “processing plant” will be damaged or devastated. The liver tissue cells are like the “hardware”, and the functioning of the “processing plant” will be weakened, decayed, or even go into failure if they are damaged. In clinical practice, liver failure is classified as a critical illness. As a result of massive necrosis of liver tissue cells, the organ’s synthesis, detoxification, metabolism, secretion, biotransformation, and immune defense functions are severely impaired or lost in compensation, and a series of clinical syndromes, such as jaundice, hepatic encephalopathy, and ascites, usually called complications, occur. Therefore, liver failure is one of the most serious clinical types of liver disease, often developing rapidly and dangerously, with a high resuscitation rate of 85% or more. Although liver failure is dangerous, as long as we take it seriously, treat it scientifically, take good care of it, cooperate with doctors and patients, be full of confidence and hold the belief of “never give up, never give up”, we can hope to snatch the patient’s life back from the death line. It has been proved that the success rate of our medical team can reach about 70%, which is the leading international level. Their approach is: First, innovation in the concept of rescue and treatment, with “cluster, individualized and refined” treatment methods, to open up the life channel for patients with “liver failure”. With the development of liver failure, patients with liver failure often have different degrees of complications inside and outside the liver, which can lead to a vicious circle and endanger their lives. Therefore, in the process of treating patients with liver failure, in addition to closely observing the degree of liver damage and timely treatment, we should pay more attention to the damage to the function of organs other than the liver, such as lung, brain, kidney and blood clotting, etc. due to liver failure. In the process of clinical treatment, we should take care of the function of organs other than liver such as lung, kidney and brain as early as possible, and give continuous organ function protection and supportive treatment in time, so as to win time and conditions for patients to control the primary disease and promote organism repair, and finally achieve the purpose of rescue success rate. Second, firmly grasp the “three nodes” to determine the treatment plan in a targeted manner. 1. Early stage of disease: accurate judgment without delay. There is a “golden window” of treatment between the emergence of liver insufficiency and the irreversible stage of liver failure. If we can accurately and timely determine this period and provide correct clinical treatment, it is of great significance to improve the prognosis of patients. The “golden window period” of liver failure patients is usually within 7 days of the rapid aggravation of the disease process, which is mainly in the pre-rising to rising stage of the disease process of liver failure. The grasp of the “window period” can play a half-measures effect, then to curb the progress of the disease, to promote the miracle of the patient to turn the crisis into peace. 2, the middle of the disease: strong measures are not loose. When the disease enters the middle stage, is the most vulnerable to other organs outside the liver, but also the most serious clinical manifestations, the most complex occasion, but also the most test of the physician’s ability and level of rescue and treatment. Physicians who dare to face this stage must make a comprehensive assessment of the patient, precise treatment, seize the fleeting opportunity to reverse the crisis. 3, the late stage of the disease: psychological guidance does not give up. Patients enter the late stage, often after a long course of disease, coupled with liver failure on sugar, fat, protein metabolism disorders of the three major nutrients, malnutrition is particularly prominent, weak condition prone to recurrence, often make the patient’s psychological burden is very heavy. In order to promote hepatocyte regeneration, improve liver function, enhance body immunity and resistance to infection and toxins, reduce the occurrence of complications, and improve disease prognosis, it is believed that in addition to providing reasonable and effective nutritional support to meet the body’s energy requirements, timely and correct psychological guidance to reduce the patient’s psychological burden and establish the patient’s belief to overcome the disease is often more important than medicine. Here we have to emphasize that although liver failure is one of the serious clinical diseases, it is not a terminal disease and is still curable. We must appeal to everyone to correctly understand the importance of the liver to human health, to pay attention to and care for the liver, not to take drugs indiscriminately, to drink excessively, to popularize the awareness and judgment of liver damage, and to achieve early prevention, early recognition and early diagnosis as much as possible. Once the liver failure disease is detected, it should be sent to a medical institution with specialized medical facilities and medical team as soon as possible in order to control the cause of the disease as soon as possible, deal with it precisely and improve the survival rate of patients.