With the improvement of people’s living standard, people pay more and more attention to the quality of life. There are many causes of headache, including neurological, cardiovascular, tumor and other factors, and in practice, headache caused by nasal and sinus diseases is an important factor. In clinical practice, we have encountered a group of patients who have frequent headaches and have visited neurology and physiotherapy departments, only to find out that it may be a problem of the nose after repeatedly tossing and turning. Headache is a subjective symptom that is clinically common, with many causes and very complex mechanisms. The local lesions and structural variants of the nasal cavity and sinuses are closely related to the occurrence of headache, among which headache caused by rhinitis, sinusitis, and nasal septal deviation is common. The causative factors of rhinogenic headache are broadly divided into two categories. First, the nasal cavity is rich in sensory nerve fibers. The sensory nerves of the nasal cavity come from the ophthalmic and maxillary branches of the trigeminal nerve. The ophthalmic branch divides the anterior sieve nerve to the anterior part of the nasal cavity, and the maxillary branch divides the lateral branches of the posterior superior and inferior nasal nerves to the middle and inferior turbinates respectively, and the anterior, middle and posterior branches of the superior alveolus to the maxillary sinus, which are responsible for the sensation outside the nose. At the same time, there are sympathetic and parasympathetic nerves in the nasal cavity, which are responsible for the vasodilation and contraction of the mucous membrane of the nasal cavity and the secretion function of the glands. Therefore, the nasal cavity is one of the more sensitive parts of the body. Secondly, the nasal cavity is actually composed of narrow cavities, holes and gaps with complex and delicate anatomical structures. Once the nasal cavity is attacked by inflammation and the anatomical structure of the nasal cavity is enlarged and mutated, it is easy to cause nasal cavity and sinus drainage obstruction, swelling and extrusion, resulting in the involvement of adjacent structures. In the early stage, it is mostly manifested as obstructive headache, due to long-term obstruction of the sinus opening, the air in the sinus cavity is gradually absorbed, the so-called “vacuum headache” appears, the vacuum state mucosal vascular expansion, a large number of serum leakage, or due to inflammation exudation and pus accumulation to increase the pressure of the sinus cavity, and “tension headache The “tension headache”. The high septal deviation and the enlargement of the septum, sieve vesicles and turbinates cause reflex headache because the nasal cavity, especially the olfactory suture, is narrowed and the middle and lower turbinates are pressurized, so that their diastolic function is restricted. Inflammation of the nasal nerve is also one of the factors that cause headache. Some headache patients should be alert to the occurrence of malignant nasopharyngeal tumors, which are common in the nasal cavity, sinuses and nasopharynx. The incidence of nasal cavity and sinus tumors can rank the 5th among all cancers in China, accounting for 2.05% to 3.66% of all malignant tumors, among which malignant tumors of sinus are more common than those originating from nasal cavity; malignant tumors of nasopharynx, especially nasopharyngeal carcinoma, are a common cancer in China. The incidence of nasopharyngeal cancer is the first among all malignant tumors in the whole body in some high incidence areas, especially in Guangdong Province. Headache caused by malignant tumors of nose and throat is mainly due to local compression, infiltration and invasion of the cancer. For example, nasopharyngeal carcinoma is usually found in the pharyngeal fossa, which is close to the rupture hole of the skull base. Therefore, headache is sometimes an important complaint of nasopharyngeal tumor, and it can appear in 1/5 patients at an early stage. Therefore, in our daily life, if we meet an older patient with headache, accompanied by nasal congestion, nasal bleeding, hearing loss, tinnitus and enlarged lymph nodes in the neck, we should be alert to the occurrence of nasopharyngeal malignant tumor. Patients with headache symptoms account for 68.6% of the total population of nasopharyngeal cancer, which shows that headache is common among patients with nasopharyngeal cancer. The headache site is relatively fixed, mostly located in the temporal, top or occipital area of the affected side or semi-lateral headache, and the headache is intermittent in the early stage, gradually worsening, and then may become persistent. However, due to the aggravation of the disease, the invasion of cancer, the destruction of skull base bone and the invasion of cranial nerve, the headache is more intense and persistent, and the pain is unbearable, and it is more prominent at night, so it is often necessary to take analgesic to relieve the headache, but it is often ineffective. About 1/3 of the patients have multiple groups of cranial nerve paralysis, among which the trigeminal nerve is most commonly involved, resulting in numbness of the affected side, deviation of the mouth, impaired eye movement, and even nerve paralysis keratitis, which causes ulceration of the cornea and is difficult to heal. Therefore, for chronic headaches that do not resolve and are followed by damage to the cranial nerves, prompt consultation with the ENT department is required to perform the necessary tests to clarify the diagnosis and carry out treatment. It is worth mentioning that the nasal cavity is the gateway to the entire respiratory tract and is most susceptible to the influence of various external physical and chemical factors and pathogenic microorganisms, and has more chances of development. Therefore, to prevent the occurrence of rhinogenic headache, the skin of the nose and the mucous membrane of the nasal cavity should be kept clean and intact frequently, and special attention should be paid to protecting the barrier role of the mucous membrane. Do not pluck nasal hairs at random and disinfect local skin when it is damaged. In case of folliculitis, sebaceous gland infection or nasal boils, do not scratch them casually, and do not squeeze them to avoid infection caused by bacteria flowing back to the skull with facial blood circulation.