The need for long-term lifelong medication for depressed patients depends on the patient’s condition; most patients can be cured with active treatment and can stop taking medication. For patients with mild depression, taking medication is not the preferred treatment option, but self-adjustment and psychotherapy are preferred. As for patients with moderate and severe depression, medication is taken for 1-3 months in the acute phase, 6-9 months in the consolidation phase, and about 1-2 years for the first episode of depression in the maintenance phase, and 3-5 years for the second episode, and only for repeated multiple episodes, that is, at least more than 3 episodes of depression, it is highly recommended to continuously maintain the drug dose for systematic and standardized treatment, the purpose of which is to prevent disease relapse. Depression is a disease with a high cure rate and a high relapse rate, special attention should be paid to the effect of the first 3 episodes and it is very critical to try to meet the duration of treatment.