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Abstract: The patient in this case is a 56-year-old woman who came to our hospital for bleeding during intercourse. After relevant tests confirmed the diagnosis of HPV infection, but no abnormal cervical lesions occurred, and medication was taken to promote HPV conversion. After 6 months of treatment, the patient’s condition was controlled and the type 52 infection was converted to negative. However, the patient still needs regular follow-up.
Basic information】Female, 56 years old
Disease Type】HPV infection
Hospital】Hunan Provincial Maternal and Child Health Hospital
Date of consultation】January 2022
Treatment plan】Medication (povidone-based suppository, recombinant human interferon alpha-2b gel, transfer factor oral solution)
Treatment period】1 day of outpatient treatment, 6 months of medication treatment
Effectiveness of treatment】HPV type 52 positive to negative
I. Initial consultation
The patient, a 56-year-old female, came to our hospital in January 2022 for bleeding after intercourse. The patient complained that she had a small amount of blood after intercourse one month before the visit, but did not pay attention to it and did not take any special treatment, but it did not improve in the past month and the discomfort persisted, so she came to our hospital. According to the patient’s complaint, she was given a gynecological examination, which indicated slight vaginal congestion and yellow discharge; vaginal discharge examination indicated vaginal cleanliness of 3°; HPV examination indicated type 52 infection with a viral infection number of 24.76, and TCT examination indicated abnormal epithelial cells. The patient was initially diagnosed with HPV infection and vaginitis, and follow-up examinations are needed to determine whether there are adverse cervical lesions.
II. Treatment history
The patient underwent electronic colposcopy and cervical biopsy to clarify her condition, and came back to our outpatient clinic after the results were available. Based on the results of these two examinations, it was possible to confirm that the patient only had HPV infection and no cervical lesions had yet occurred. I explained this situation to the patient, who was relieved and readily agreed when I suggested that the next best thing to do was to cooperate with medication to help HPV turn negative. So, according to the patient’s condition, I prescribed povidone-based suppositories and recombinant human interferon alpha-2b gel to be used topically alternately. At the same time, considering the patient’s age and poor self-resistance, I added transfer factor oral solution to help increase the patient’s resistance and speed up the HPV conversion.
III. Treatment effect
The patient was treated with medication on time and came to our outpatient clinic for follow-up three months after the initial visit. Although the HPV was still positive, the virus count had dropped to 15.7, indicating that the patient’s condition was improving. At the end of the follow-up visit, the patient continued to use medication and successfully turned negative for type 52 positive at the second follow-up visit, which was 6 months later, indicating that the treatment regimen was effective for the patient, but the patient still needs regular outpatient follow-up to monitor the effect of treatment.
IV. Precautions
The patient was very happy that her HPV infection was initially controlled and her condition improved after 3 months of treatment, and I was also glad for the patient’s improvement. At the same time, the patient was also instructed to take regular and quantitative medication and not to stop it at will to ensure that the HPV can be successfully transferred to the negative side; she should also pay attention to good protection measures during intercourse to avoid cross-infection. In addition, it is necessary to pay attention to daily life care, appropriate exercise in daily life, such as yoga, jogging, etc.; diet should pay attention to the meat and vegetables to ensure a balanced intake of nutrition; because these also have a positive effect on the body’s resistance, which is conducive to HPV conversion.
V. Personal insight
Patients with confirmed HPV infection should first undergo TCT and colposcopy to determine their current condition. If, as in the case of the patient in this article, only HPV infection is present, the patient should start by improving her own resistance and using her immune system to kill the HPV virus completely. This should be coupled with maintaining healthy habits such as moderate exercise, balanced diet and regular work and rest to help improve one’s resistance and speed up HPV conversion.