After I published an article on the surgical treatment of penile shortening, some readers approached me to solve “infertility caused by penile shortening”; many of them asked about the risks and effectiveness of the surgery, and what kind of treatment effect could be achieved; more questions were asked about the methods to treat penile dysplasia without surgery. In addition to the severe short deformity of penile dysplasia, which prevents normal sexual intercourse, the size of the penis is not related to fertility, which depends on the normal sperm production and delivery functions of the testes and accessory glands. And the concept and technology advances, in the treatment of penile dysplasia there has been some progress. First, the lengthening surgery is gradually mature and the results are reliable Patients with short penis have a serious sense of inferiority, which affects the quality of sexual life and urgently require effective treatment. Johnston in Britain reported in 1974 the application of surgery to release the penile suspensory ligament to treat congenital or acquired factors caused by penile shortening. In China, the corresponding surgery was gradually carried out in the 1990s, and the technology has gradually matured. We were the first to carry out penile lengthening surgery for short penis in our region in 1992, and achieved precise and reliable treatment results. With the progress of the concept of improving the level of reproductive health, the safety of surgery and the role of improving sexual physiological functions have gradually been recognized, and the lengthening surgery for penile shortening has now been written in authoritative works. At present, there are many kinds of lengthening surgery for penile shortening at home and abroad. The penis can be lengthened by 3 ~ 5 M after the lengthening surgery, and the penis can be lengthened surgically for those who are really short due to penile dysplasia or trauma, which affects the quality of sexual life and who firmly request surgical correction, but the indications must be strictly controlled. Second, the drug treatment of penile dysplasia Out of the original reproductive worship and the need to improve the function, the ancients in the application of drugs to promote the development of the genitalia have done a lot of exploration. The Chinese Tang dynasty’s “Dongxuanzi”, a special book on health and wellness, recorded a method to promote penis growth, called “long yin formula”, using Cistanches and seaweed as raw materials, plus the liver juice of white dogs, applied to the male penis, which was said to be extremely effective. Of course, the ancient people were limited by the medical technology at that time, and some of the methods still need to be further verified. Modern medicine can treat penile dysplasia with a clear diagnosis and indications for treatment through medication. For example, in patients with Creutzfeldt-Jakob syndrome, due to an extra X chromosome than normal males (often manifested as 47XXY), such patients have a long and slender body, no beard pubic hair, and a small penis like a child. Treatment with chorionic gonadotropin or testosterone can improve the development of external genitalia and secondary sexual characteristics to maintain sexual function. It is generally believed that after the male reaches maturity around the age of 25, the external genitalia will no longer grow, just like the height, therefore, penile dysplasia before maturity can be treated by adjusting the endocrine function. However, the structure of the penis is a hollow spongy organ filled with vascular sinuses, and its length and size are closely related to the elasticity and filling condition of the spongy body. Therefore, some adult patients with mild external genital dysplasia may not be suitable for treatment with hormonal drugs, but they can improve their condition with effective prescriptions. The latest class of potent drugs for impotence – PDE5 inhibitors – has also been proposed for its possibility of improving penile shortening due to its ability to effectively enhance cavernous diastole. The latest class of effective drugs to treat impotence – PDE5 inhibitors – has been proposed as a possibility to improve penile shortening due to its ability to effectively enhance cavernous stretching. In 1960, Geddings Osbon designed and developed the vacuum constriction device (VCD), which was approved by the FDA in 1982, and since then various negative pressure suction devices have been introduced and are widely used worldwide. In 1988, we started to apply a “male function therapy device”, which is an improved version of VCD, a male rehabilitation device using the principle of continuous negative pressure for erection, with negative pressure, temperature-controlled water massage, electromagnetic pulse oscillation and ion introduction, combined with herbal treatment solution. The treatment of male sexual dysfunction and penile shortening has a certain effect. The treatment mechanism is: 1, negative pressure: through repeated negative pressure attraction to fill the cavernous body, increase the partial pressure of oxygen and restore the elasticity of the white membrane of the cavernous body; 2, traditional Chinese medicine: the introduction of kidney aphrodisiacs and blood-activating drugs and the stimulating effect of electromagnetic waves on the ganglion; 3, soft tissue expansion: soft tissue expansion has been applied for a long time in human history and has become one of the conventional treatment means of plastic surgery; through the method of mechanical pulling to achieve stimulation of tissue growth. Repeated negative pressure attraction through soft tissue expansion effect can make the penis length and circumference to get some growth, but circumferential expansion seems to be more obvious. In patients with severe penile shortening, the use of penile lengthening surgery followed by treatment with negative pressure instruments is more ideal.