Mental illness is not a contraindication to rabies vaccination, and it is possible if necessary. Rabies vaccination is currently the most effective way to prevent rabies because of its high mortality rate and poor therapeutic efficacy, so it is important to prevent the disease. The rabies vaccine has a certain timeliness, and it is generally recommended to get the vaccine within 24 hours of the injury, so it is also recommended to get the vaccine within this timeframe for patients with mental illnesses in order to achieve effective prevention. Mental illness is not a contraindication to rabies vaccination, and the pros and cons of rabies vaccination need to be weighed. After the rabies vaccine is administered, the patient should be observed at the vaccination site for more than 30 minutes to see if there are any adverse reactions associated with the vaccine, so that it can be dealt with in a timely manner.