Patient: The patient is a female, 35 years old, previously in good health and working in an office. This condition: 1. By ultrasonography, two hypoechoic nodules with clear borders and inhomogeneous internal echogenicity were seen in the left lobe, within which punctate strong echogenicity was visible, with sizes about 4.9MM*4.1MM and 2.5MM*2.4MM, and punctate blood flow signal was visible. 2. A hypoechoic nodule with a size of about 7MM*3.7MM and clear borders was seen on the left clavicle. It has not been treated. 1. Can it be determined by ultrasonography to be malignant or benign, and does it require surgical treatment at this time? 2.If surgical treatment is not required, please advise the next treatment plan. Jia Hongli: According to the ultrasound description, malignancy is likely, but not all nodule calcification is malignant. To determine whether the calcification is malignant, if it is sand-like calcification is a typical malignant feature, other atypical ones depend on the level of the ultrasonographer. If the nodule is cold, surgery is recommended, and if the nodule is found to be malignant, 131I treatment must be given in a timely manner after surgery, one or the other is indispensable, unless low malignancy stage I patients can, in principle, not do I treatment, but in practice, for safety most patients and most hospitals have to take at least one I treatment.