First decoction and prolonged decoction of epiphyllum can reduce its toxicity, and reasonable combination of other drugs can also reduce its toxicity and avoid poisoning. It is a very commonly used traditional Chinese medicine, which has the effect of restoring yang to save the body (by warming yang qi to save fainting, unconsciousness, etc.), tonifying fire to help yang (replenishing the body’s yang qi), and dispersing cold and relieving pain (by dispelling the body’s cold to relieve pain), and it has a better therapeutic effect when used appropriately. Epiphyllum is a more toxic drug, containing a variety of aconitine compounds, while studies have found that after long-term decoction of epiphyllum, aconitine can be hydrolyzed to aconitine, which greatly reduces the toxicity. When decocting traditional Chinese medicine containing aconite, aconite should be decocted with sufficient water for 1 to 2 hours or until the mouth tastes no pungency to the extent that it should be added with sufficient water at one time, and cold water should not be added in the middle of the decoction, otherwise its toxicity will be increased. In addition, according to the theory of traditional Chinese medicine, rationally matching the application of traditional Chinese medicine can reduce the dosage of epiphyllum and improve the efficacy of traditional Chinese medicine and medication safety. For example, the Si-Reverse Tang, which is composed of epiphyllum with dry ginger and licorice, is a representative formula to restore yang and save reverse, and the decoction of these three medicines can decompose the aconitine in epiphyllum, which greatly reduces the toxicity. The decoction of Chinese medicine has the saying of “decocting first and decocting later”, and the toxic medicine such as epiphyllum should be decocted first, and the time of decoction should be long, so as to reduce the toxicity of the medicine. Specific medication and usage need to strictly follow the doctor’s instructions, do not blindly use their own medication, in order to prevent poisoning.