According to national and international statistics, the prevalence of depression in women is usually twice as high as in men in different countries and ethnic groups. Women do belong to a special group of depression, and what is often referred to as postpartum depression, menopausal depression, premenstrual tension, mood during pregnancy, etc. can usually be associated with female depression. The reason why this difference occurs was usually thought to be due to the family, environmental, and social pressures that women endure, but estrogen has now been clearly found to be closely associated with the onset of depression. Estrogen is a female hormone that is mainly secreted by the ovaries, which begin to develop when girls reach puberty and secrete estrogen at the same time. Although the amount of estrogen in the body is small, its impact is enormous and it cannot be replaced by any hormone. The monthly menstrual cycle, pregnancy, postpartum, and menopause are all associated with fluctuations and changes in estrogen, thus causing women to be prone to depression during these special stages, and some experts have explored the use of estrogen to treat depression in menopausal women, which can significantly improve the symptoms of depression. Why? Estrogen can cause depression when it is either falling or rising. The reason is that estrogen and the hormones that cause depression, such as dopamine and adrenaline, are unified and regulated by the higher centers of the brain, influencing and regulating each other. Therefore, for women with depression, when applying antidepressants, attention to regulating the disordered estrogen will facilitate the improvement of depressive symptoms and speed up the healing of the disease.