Premature ovarian failure (POF) is a state of low hormones (E2 < 25 pg/mL) and high gonadotropins (FSH > 4o Iu/L and LH > 30 IU/L) that occurs before the age of 4o years, and its incidence accounts for 1 – 3% of women. patients with POF may present with infertility and a range of symptoms due to low estrogen levels in the body, such as facial flushing, bouts of heat and sweating, and osteoporosis. It seriously affects the quality of life of women. The etiology of POF is complex and not yet well understood. Modern medicine believes that the causes of premature ovarian failure include: autoimmune abnormalities, genetic factors, gonadotropin and its receptor transmission defects, physicochemical factors, enzymatic defects (such as galactosemia, mucopolysaccharidosis, 17–a hydroxylase defects, etc.). Among them. The prevalence of autoimmune abnormalities is high. It occupies an important position. Theoretically, the pathogenesis of POF is congenital low follicular number, increased follicular atresia, and impaired follicular maturation. In Chinese medicine, this disease belongs to the category of “blood depletion”, “blood isolation”, “amenorrhea” and “infertility”. The causes of this disease can be summarized as follows: 1. Insufficient congenital endowment and kidney qi. The Qi and blood of the sphincter are not full and gradually become exhausted. 2. Internal injury of the seven emotions. Causes liver depression, Qi stagnation and blood stasis. Stagnation of Qi and blood. Dark depletion of Qi and blood; or excessive thinking. Damage to the heart and spleen. Menorrhagia is caused by the failure of the spleen. 3, the disease is long sickness and depletion of yin, or room labor, multiple births, abortion, miscarriage, etc., depletion of essence and blood, and premature failure of the ramification. 4, during menstruation, after childbirth, the external sensation of six evil spirits. With the blood, stasis obstructs the stroke, resulting in menorrhagia. 5, physical and chemical factors. Such as radiotherapy, chemical drugs, long-term use of anti-rheumatic drugs such as rheumatism can lead to this disease. Modern doctors have different understanding of the pathogenesis of the disease, but always take kidney deficiency as the leading cause. Kidney deficiency and deficiency of the punching point, the sea of blood is empty. The absence of blood is the main pathogenesis of the disease. Professor Luo Yuankai believes that kidney deficiency is the main pathological basis of premature ovarian failure. It is also believed that the disease is caused by depletion of kidney water resulting in yin deficiency and fire, and the failure of the rhizome. In addition to kidney deficiency. Liver depression, spleen deficiency, and imbalance of qi and blood are also important pathogenic mechanisms of menorrhagia. When the evidence. Often a variety of pathogenic mixed, interchangeable, and make the disease lingering difficult to cure. The pathogenesis includes deficiency of kidney yang, liver, kidney yin deficiency, qi deficiency and blood stasis, liver depression and qi stagnation. Spleen and kidney yang deficiency, liver and kidney yin deficiency, kidney deficiency and liver stagnation, and heart and kidney disconnection can all lead to premature failure of the flush and amenorrhea. Treatment Throughout the present stage of premature ovarian failure, most of the diagnostic and therapeutic treatments use a combination of modern medical diagnostic techniques and TCM theory to identify and treat the disease, thus improving the level of diagnosis and efficacy. After detailed questioning of the patient’s history of immune diseases, family history, exposure to physical and chemical factors and viral infections, clinical manifestations such as low estrogen symptoms, amenorrhea, menopausal syndrome and Gn measurement, laparoscopy or ovarian biopsy were mainly used. If FSH>401u/L or LH>3OIu/L and E2<25pg/m1, the diagnosis can be made in combination with clinical findings. After the diagnosis of premature ovarian failure is confirmed clinically, treatment can be carried out according to the method of TCM evidence-based treatment. Wen Hongyan divided the disease into 4 types: kidney-yang deficiency type; liver-kidney yin deficiency type; qi deficiency and blood stasis type; and liver-depression and qi stagnation type. Chen Xiufang divided the treatment into 3 types: liver and kidney yin deficiency type: nourish the liver and kidney, nourish the blood and activate the blood; qi deficiency and blood stasis type: use the method of benefitting the qi and activating the blood to open the meridians; phlegm and dampness obstruction type: treat by benefiting the kidney and strengthening the spleen. The treatment is to benefit the kidneys, strengthen the spleen, resolve blood stasis and expel phlegm. Wang Xuan divided 47 patients with premature ovarian failure into 3 types: kidney-yang deficiency, liver-kidney-yin deficiency and kidney-deficiency-liver-depression type, all of which were treated with Xianle Xiong capsule. Xu Ping used nourishing the kidney and cultivating the yuan. She treated premature ovarian failure with nourishing the kidney, cultivating the essence, and regulating the flushing of the nerves. Zhang Yaping et al. used Tonic Xian Tonic Tang, which nourishes the kidney, tonifies the liver, and nourishes blood to regulate menstruation. The basic principles are: during follicular development, it is advisable to nourish the kidney, nourish the blood, regulate the flushing and balance the kidney qi. The basic principles are: the follicle development period should be nourished by nourishing the kidneys, nourishing the blood, regulating the flushing and taking care of the kidney qi. During the luteal phase, it is advisable to warm the kidney yang to maintain normal luteal function; during the menstrual phase, it is advisable to invigorate the blood to regulate menstruation and to promote normal menstruation by taking advantage of the situation. On this basis. Xing Cuiling used Chinese herbal cycle therapy: late menstrual period: strengthen the spleen and tonify the kidneys, regenerate blood and invigorate blood. Pre-menstrual period: nourish the liver and kidney. Nourishing Blood and invigorating Blood. Menstrual period: regulating the flushing of the body and invigorating Blood. The etiology and pathogenesis of premature ovarian failure are complex and difficult to treat. Therefore, clinical treatment should be based on a combination of Chinese and Western medicine to identify the causes and symptoms. The treatment should be combined with Chinese and Western medicine. The treatment can be more effective. POF has a complex etiology and the pathogenesis is still unclear. Its western medical treatment is mainly symptomatic, mostly using the artificial cycle therapy of estrogen and progestin, the treatment effect is not exact, and easy to relapse after stopping the drug, long-term medication is potentially dangerous, not easy for patients to accept. Chinese medicine has a multi-systemic and multi-linked overall regulating effect, which can improve ovarian responsiveness to gonadotropins, thus restoring and improving ovarian function, and is safe and effective for clinical use. In our hospital, the main treatment is based on tonifying the kidney, strengthening the spleen, draining the liver, nourishing the heart and calming the mind, etc. According to the patient's needs, sex hormone supplementation therapy is applied appropriately.