Ovaries are one of the most important reproductive organs in the female body, and if premature ovarian failure occurs, it can have a great impact on our fertility! And for women who love beauty, skin, body overall adverse effects, the early arrival of menopause, followed by the advent of aging. This is the reason why the society beauty salon various names ovarian maintenance, earn the eyes and money of women. So what is premature ovarian failure? 1, the definition of premature ovarian failure: premature ovarian failure (POF) refers to a syndrome in which women develop amenorrhea before the age of 40, follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels are elevated (FSH>40IU/L), and estrogen levels are reduced. 2. Prevalence of premature ovarian failure: 0.3-3%. It accounts for 20-25% of primary amenorrhea and 10-20% of secondary amenorrhea. POF without genetic or medical factors is not uncommon in adolescents. Age of onset of premature ovarian failure: Ovarian failure can occur at any age, with a high incidence at 30-40 years of age. It is most common in middle-aged women around 25 years old and around menopause, but it also occurs in young girls under 20 years old. The causes of premature ovarian failure: (1) Ovarian surgery: partial removal of ovaries, ovarian cyst removal or removal of one side of the adnexa, as well as radiation therapy and chemotherapy can affect the ovaries and lead to premature ovarian failure. (2) Genetic factors: X chromosome deletion or aberration can lead to atrophy and degeneration of already formed follicles. Most of the follicles have degenerated before birth, and occasionally the few that do not degenerate are retained until after puberty, when the patient presents with secondary amenorrhea. (3) Immune factors: Premature ovarian failure is often complicated by thyroiditis, systemic lupus erythematosus, rheumatoid arthritis and so on. In this case, the patient has anti-ovarian antibodies in the peripheral blood, which, when combined with the corresponding cells in the follicles, can damage the follicles and lead to ovarian failure. (4) Idiopathic premature ovarian failure: premature menopause without clear causes, with karyotype 46XX and usually no autoimmune antibodies measured. 4. Treatment of premature ovarian failure: The current treatment in Western medicine is hormone replacement therapy (HRT). However, because of long-term replacement, side effects are obvious, and patients outside the contraindications of hormone application. It is necessary to seek non-hormonal treatment. Chinese medicine is indeed much safer compared to hormone therapy. And the effects are long lasting. It also has the advantage of safety and no side effects. Usually, our women’s gynecological diseases are not easily detected because they are vague in terms of symptoms, which can easily lead us to make wrong judgments and thus delay the treatment. Patients with premature ovarian failure show changes in menstruation and symptoms of low estrogen. It is time to visit the hospital.