Women who suffer from premature ovarian failure and have not yet had children are very eager to restore their ovarian function through treatment. However, we regret to inform you that once ovarian function begins to fail, it cannot be restored, just as human beings cannot be stopped from growing old, getting sick and dying. As we mentioned earlier, the number of follicles in a woman’s follicular pool is predetermined by birth and cannot be regenerated if they are depleted. If ovarian function cannot be restored, why do we need treatment? Many patients may give up on themselves – what am I treating for? For patients with premature ovarian failure, the most important treatment is estrogen replacement therapy to relieve menopause-like symptoms such as hot flashes and night sweats, to prevent long-term complications (such as osteoporosis, cardiovascular disease, progeria, etc.), and to prevent uterine atrophy for future “egg donation embryo transfer” (i.e., borrowing someone else’s eggs). The patient’s husband’s sperm is used for in vitro fertilization, and the fertilized embryos are transferred to the patient’s body. Voices of patients with premature ovarian failure: Can I still be a mother? Many patients are not resigned to the fact that they still desire to be mothers. Although current research has found that 50% of patients with premature ovarian failure experience intermittent ovulation, especially in younger patients who are treated with artificial cycles using all-natural hormones, it is possible to stimulate ovulation, but it is by no means a high probability event. There is no way to predict when this ovulation will occur through, for example, basal body temperature or ultrasound monitoring, and like a shooting star in the sky, the chances of a patient getting pregnant naturally remain slim. Therefore, patients who are expecting to get pregnant are advised not to blindly wait for natural pregnancy and waste the precious time to help them conceive. In addition, some patients ask if ovulation promotion is possible, that is also not advisable. Because your ovaries have already failed and your follicles are scarce or even depleted, using medication to promote ovulation is a waste of time and money. It is better to change your mindset and undergo egg donation embryo transfer if your financial situation allows. To prepare the endometrium for egg donation embryo transfer As a patient with premature ovarian failure, if you are ready to receive egg donation embryo transfer, you must first prepare a good environment for implantation – the uterus. Some patients ask what to do if their uterus is small. Such patients should not worry too much. With systematic hormone replacement therapy, the condition of the uterus can be improved. However, it is important to note that even if the transplant is successful, hormone replacement therapy should continue until the placenta forms and can secrete hormones on its own. Therefore, patients with premature ovarian failure should also take medication as prescribed by their doctors after transplantation. Some patients also ask if ovarian transplantation can be used to treat premature ovarian failure. First of all, ovarian transplantation is not yet mature and it is not listed as a legal treatment in China, so patients are advised not to listen to rumors and try it easily.