When the immune function of the body is activated in patients with hepatitis B, the immune system recognizes the antigenic material of the hepatitis B virus and the infected hepatocytes and reacts by clearing the virus, which is a self-protective reaction of the body. As a result, a large amount of virus is cleared, while the infected liver cells are also destroyed, resulting in elevated transaminases and sometimes bilirubin. Experts point out that this clearance is often incomplete, and that viruses that are not replicating are often not killed and are latent. When the body’s immunity decreases, the virus starts to replicate again, infecting new liver cells and leading to a new round of immune attack. This repeated process of clearance and destruction, and then clearance and destruction again, is how chronic hepatitis develops. As the virus is cleared from the blood, anti-HBe appears in the serum and HBeAg disappears, and the person changes from major hepatitis B to minor hepatitis B. It can be seen that the ability to move from major to minor hepatitis B symbolizes for most hepatitis B patients a decline in viral replication in the body, a decrease in the number of viruses, and sometimes even undetectable viruses in the blood. Although there is no direct correlation between major or minor hepatitis B triplet and the severity of liver damage, there are fewer infected liver cells when the virus is reduced, and the immune response and liver damage are reduced. Therefore, we always hope that it will be beneficial to the patient to convert from major to minor hepatitis B triplet so that the virus replication will drop to the lowest level.