Patients with chronic hepatitis B who have childbearing requirements and for whom treatment is indicated should try to apply interferon or NAs before pregnancy with a view to completing treatment six months before conception. Reliable contraception should be used during treatment. For patients with hepatitis B episodes during pregnancy, mild elevation of ALT can be closely observed, and for those with more severe liver lesions, antiviral therapy with tenofovir (TDF) or telbivudine (LDT) can be used after full communication with the patient and weighing the pros and cons. For patients with unintended pregnancy during antiviral therapy, termination of pregnancy is recommended if interferon therapy is applied. If oral NAs drugs are applied: if pregnancy class B drugs (LDT or TDF) or LAM are applied, the treatment can be continued with full communication and weighing the pros and cons; if ETV or ADV are applied, the treatment should be switched to TDF or LDT to continue the treatment, and termination of pregnancy is not recommended with full communication and weighing the pros and cons. High serum HBV DNA load in pregnant patients is one of the high-risk factors for mother-to-child transmission; standard hepatitis B immunoprophylaxis for newborns and effective antiviral therapy for mothers can significantly reduce the incidence of mother-to-child transmission of HBV. If HBV DNA load is greater than 2×106 IU/ml in mid- to late-pregnancy, TDF, LDT, or LAM can be given starting from the 24th to 28th week of gestation after full communication with the patient and weighing the advantages and disadvantages.It is recommended to discontinue the medication at 1 to 3 months postpartum, and breastfeeding can be allowed after the discontinuation of the medication. Fertility of male antiviral therapy patients: male patients treated with interferon should be considered to have children only 6 months after stopping the drug; male patients treated with NAs antiviral therapy, there is no evidence of adverse effects on spermatozoa, and can be considered to have children under the premise of full communication with the patient.