Patients with chronic kidney disease (CKD) commonly have secondary hyperuricemia due to impaired uric acid excretion, but blood uric acid levels may vary at different stages of CKD, and thus the relationship to the progression of chronic kidney disease and to the occurrence of cardiovascular events may be different. For this reason, we analyzed the changes in blood uric acid levels in our dialysis-treated patients with end-stage CKD, i.e. CRF, and explored their relationship with cardiovascular events. 1. Subjects and methods 1.1 Subjects A total of 122 dialysis patients were hospitalized or ambulatory in our hospital from January to December 2007, whose primary diseases were diabetic nephropathy in 45 cases, chronic glomerulonephritis in 44 cases, hypertensive benign renal small artery sclerosis in 24 cases, autosomal dominant polycystic kidney disease in 4 cases, and other types in 5 cases. There were 55 male and 67 female cases, mean age (54±14) years; GFR<15ml/min. regular dialysis for more than 3 months, dialysis 2-3 times a week, bicarbonate dialysis solution dialysis. There were 58 cases in the elevated blood uric acid group (UA≥440mmol/L) and 64 cases in the normal blood uric acid group (UA<440mmol/L). Blood total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), C-reactive protein (CRP), tumor necrosis factor (TNF-a), fibrinogen (Fbg) and blood creatinine (SCr) were routinely measured. 1.2 Measurement methods All subjects were fasted for 10 h and upper limb venous blood was taken in the early morning on an empty stomach, and all assays were completed on the same day. 1.3 Diagnostic basis of cardiovascular events Including myocardial infarction, myocardial ischemia, arrhythmia, left ventricular enlargement, confirmed by echocardiography and electrocardiography. 1.4 Statistical treatment Count data were analyzed by x² test, measurement data by mean ± standard deviation (¯x ± s), comparison of means between groups by t-test, and correlation analysis by Pearson correlation analysis. All data were processed using SPSS13.0 software package. p<0.05 was considered statistically significant difference. 2, Results The comparison of indicators and correlation analysis of inflammatory factors between the group with elevated uric acid and the group with normal uric acid showed that in this group, their blood UA levels were positively correlated with LDL concentration, TNF-a (P<0.05), TG, TC, CRP, Fbg and SCr (P<0.01); and negatively correlated with blood HDL concentration (P<0.01). Also our results showed that blood UA levels were positively correlated with echocardiographic abnormalities, ECG abnormalities and cardiovascular events (P<0.01), systolic and diastolic blood pressure (P<0.05); and not with age, gender, hemoglobin and blood albumin.