In 1950, British pharmacologists Hench and Kendall were awarded the Nobel Prize in Medicine for their discovery of glucocorticoids (hereafter referred to as hormones) and conclusive proof of their effectiveness in the treatment of rheumatic diseases. Over the decades, the miraculous effect of glucocorticoids in medicine has saved countless patients’ lives. However, they have also been criticized and criticized for their irrational application and even abuse, and can be said to have a mixed reputation. Medical professionals feel “loved and feared” and do not know what to do. To most people, it is still like a flower in the fog and a moon in the water, and it is difficult to be seen in a real way. Because of the vague understanding of hormones, lay people and the general public are afraid to hear the mention of hormones, thinking how great the side effects are, which makes many patients lose the best treatment opportunity. For more than half a century, scientists have never stopped researching this miraculous drug and have developed a series of hormone-like drugs such as cortisone, hydrocortisone, prednisone, prednisolone, methylprednisolone, dexamethasone, betamethasone and tretinoin. Different drugs have different mechanisms of action and side effects and different indications. Medical personnel should select different hormone treatments according to different diseases and apply them skillfully, which will minimize the side effects. Hormones can achieve dramatic effects in the treatment of certain acute and critically ill patients. For example, bronchial asthma, anaphylaxis, myasthenia gravis, life-threatening stress states, infections, etc. Hormones are most widely used in the field of nephropathy and rheumatic-immune diseases. For example, nephrotic syndrome, acute progressive nephritis, lupus nephritis and vasculitis are the best indications for hormones. 1.But the abuse of hormones can cause serious side effects, specifically: adrenal gland: adrenal atrophy, Cushing’s syndrome; 2.cardiovascular system: hyperlipidemia, hypertension, atherosclerosis, thrombosis; 3.central nervous system: behavioral, cognitive, memory and mental changes; 4.gastrointestinal system: gastrointestinal bleeding, pancreatitis, peptic ulcer; 5.immune system: low immunity, susceptible to Skin: atrophy, delayed wound healing, erythema, hirsutism, perioral dermatitis, glucocorticoid-induced acne, purple lines, and capillary dilation; 7, skeletal muscle system: osteonecrosis, muscular atrophy, osteoporosis, delayed growth of long bones; 8, eye: cataract, glaucoma; 9, kidney: water and sodium retention, hypokalemia; 10, endocrine system: suppression of the endogenous pituitary-hypothalamus axis leads to renal failure. 10, endocrine system: suppression of the endogenous pituitary-hypothalamus axis leads to adrenal atrophy and hypoadrenocorticism, steroidal diabetes; 11, reproductive system: delayed puberty, fetal growth retardation. Hypogonadal changes. Hormones are a double-edged sword, and they must be used under the guidance of a specialist, who should not hesitate to sign the notification letter when they are used, strictly follow the medical prescriptions for treatment, and closely monitor the side effects. The so-called rational application includes hormone dosage, dose, usage, duration of treatment, reduction methods, and combined medications. The side effects of hormones can be predicted and prevented by mastering the medication technique, so there is no need to worry too much. Do not refuse to apply hormones because of a one-sided understanding of hormones and delay the best time for treatment.