The patient is a 43-year-old female, mother of two children, who was treated externally 20 years ago for a “cervical and mediastinal tumor”. 10 years ago, the tumor recurred and invaded the cervical vertebral body and involved the spinal canal. During the course of the disease, the patient went to many hospitals across the country and was told that the tumor could not be surgically removed. The patient’s cervicothoracic CT indicated lower cervical and mediastinal tumors with bone destruction of the cervical vertebrae 4, 5, 6 and 7. Some colleagues thought that it was not worthwhile to take such a big risk for the patient to perform surgery under the current medical environment. However, because of the serious bone destruction of the vertebrae, the patient could be paraplegic or even die at any time if not treated surgically. The cardiothoracic surgery department, together with the orthopedic department and the anesthesiology department, repeatedly discussed the patient’s condition and treatment plan. After adequate preoperative preparation, the patient’s tumor was removed and the cervical bone graft was fused and internally fixed with the anesthesiology department. At 9:00 p.m. on the night of surgery, the patient woke up fully and moved his limbs freely. At present, the patient has successfully recovered and discharged from the hospital. The surgical treatment of mediastinal tumor in our hospital is ahead of the domestic counterparts, and our experience in treating huge mediastinal tumor was introduced in the national annual meeting of cardiothoracic surgery in 2014, which was unanimously recognized by the counterparts at home and abroad.